Abstract
We selected 42 patients with bipolar disorder type I (BPI) and 40 healthy controls for genetic analysis of DNA polymorphisms in the serotonin receptor 2c (5-HTR2c) and serotonin transporter (5-HTT) genes. No significant associations were found in the total patient sample. However, when the individuals were divided according to gender, trends for association with both polymorphisms (P = 0.051 for 5-HTR2c and P = 0.049 for 5-HTT) in female patients were observed. These results suggest that variations in these genes may be responsible for a minor increase in susceptibility for bipolar disorder in women.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Bipolar Disorder / genetics*
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Carrier Proteins / genetics*
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Female
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Humans
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Male
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Membrane Glycoproteins / genetics*
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Membrane Transport Proteins*
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Middle Aged
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Nerve Tissue Proteins*
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Polymorphism, Restriction Fragment Length
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Receptor, Serotonin, 5-HT2C
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Receptors, Serotonin / genetics*
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Serotonin / genetics
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Serotonin / metabolism*
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Serotonin Plasma Membrane Transport Proteins
Substances
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Carrier Proteins
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Membrane Glycoproteins
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Membrane Transport Proteins
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Nerve Tissue Proteins
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Receptor, Serotonin, 5-HT2C
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Receptors, Serotonin
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SLC6A4 protein, human
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Serotonin Plasma Membrane Transport Proteins
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Serotonin