Hydantoin syndrome with holoprosencephaly: a possible rare teratogenic effect

D Kotzot; J Weigl; W Huk; H D Rott

doi:10.1002/tera.1420480105

Hydantoin syndrome with holoprosencephaly: a possible rare teratogenic effect

Teratology. 1993 Jul;48(1):15-9. doi: 10.1002/tera.1420480105.

Authors

D Kotzot¹, J Weigl, W Huk, H D Rott

Affiliation

¹ Institute of Human Genetics, University of Erlangen, Germany.

PMID: 8351644
DOI: 10.1002/tera.1420480105

Abstract

We report on a newborn girl with lobar holoprosencephaly and clinical signs of hydantoin syndrome. During pregnancy the mother was treated with diphenylhydantoin and primidon for psychomotor and petit mal seizures. The possible relationship between hydantoin syndrome, holoprosencephaly, and maternal intake of anticonvulsants during pregnancy is discussed.

Publication types

Case Reports

MeSH terms

Abnormalities, Drug-Induced*
Female
Holoprosencephaly / chemically induced*
Holoprosencephaly / diagnostic imaging
Humans
Infant, Newborn
Magnetic Resonance Imaging
Phenytoin / adverse effects*
Radiography
Syndrome

Substances

Phenytoin