Abstract
We have isolated a novel mouse gene, MFH-1 (mesenchyme fork head 1) that is related to the Drosophila fork head and rat HNF3 genes. MFH-1 encodes a distinct fork head domain that is classified into a distinct subfamily. A recombinant MFH-1 protein could bind to the HNF3 binding site. MFH-1 is expressed temporally in developing embryos, first in the non-notochordal mesoderm and later in areas of mesenchymal condensation in the trunk, head, and limbs. Our results suggest that MFH-1 might be involved in the formation of special mesenchymal tissues.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Brain / metabolism
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DNA-Binding Proteins / chemistry
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DNA-Binding Proteins / genetics*
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Drosophila
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Embryo, Mammalian / metabolism
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Embryo, Nonmammalian
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Embryonic and Fetal Development
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Forkhead Transcription Factors
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Gene Expression*
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Hepatocyte Nuclear Factor 3-alpha
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Hepatocyte Nuclear Factor 3-beta
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Hepatocyte Nuclear Factor 3-gamma
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Mesoderm / metabolism*
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Mice
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Molecular Sequence Data
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Nuclear Proteins / chemistry
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Nuclear Proteins / genetics
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Polymerase Chain Reaction
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RNA, Messenger / analysis
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Rats
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Sequence Homology
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Transcription Factors / chemistry
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Transcription Factors / genetics*
Substances
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DNA-Binding Proteins
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Forkhead Transcription Factors
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Foxa1 protein, mouse
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Foxa1 protein, rat
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Foxa2 protein, mouse
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Foxa2 protein, rat
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Foxa3 protein, mouse
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Foxa3 protein, rat
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Hepatocyte Nuclear Factor 3-alpha
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Nuclear Proteins
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RNA, Messenger
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Transcription Factors
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mesenchyme fork head 1 protein
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Hepatocyte Nuclear Factor 3-gamma
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Hepatocyte Nuclear Factor 3-beta