Two CA/GT repeat polymorphisms in intron 27 of the human neurofibromatosis (NF1) gene

C Lázaro; A Gaona; X Estivill

doi:10.1007/BF00212039

Two CA/GT repeat polymorphisms in intron 27 of the human neurofibromatosis (NF1) gene

Hum Genet. 1994 Mar;93(3):351-2. doi: 10.1007/BF00212039.

Authors

C Lázaro¹, A Gaona, X Estivill

Affiliation

¹ Molecular Genetics Department, I.R.O., Hospital Duran i Reynals, Catalunya, Spain.

PMID: 8125490
DOI: 10.1007/BF00212039

Abstract

We describe two polymorphic microsatellites in intron 27 of the neurofibromatosis type 1 (NF1) gene. The microsatellites consist of TG/AC and AC/TG dinucleotide repeats detecting five and seven alleles and with heterozygosities of 0.46 and 0.72, respectively. These microsatellites are useful tools both for direct and indirect genetic analysis of NF1.

MeSH terms

Alleles
Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 17
DNA, Satellite
Gene Frequency
Genes, Neurofibromatosis 1*
Humans
Introns*
Molecular Sequence Data
Polymerase Chain Reaction
Polymorphism, Genetic*
Repetitive Sequences, Nucleic Acid*

Substances

DNA, Satellite

Associated data

GENBANK/L03723