Human genetics. What is good about cystic fibrosis?

Curr Biol. 1994 Aug 1;4(8):742-3. doi: 10.1016/s0960-9822(00)00166-4.

Abstract

The remarkably high level of cystic fibrosis mutations among Caucasians may be due to a reduction in heterozygotes in the severity of the diarrhea caused by enterotoxic bacteria.

Publication types

  • Review

MeSH terms

  • Chlorides / metabolism
  • Cystic Fibrosis / genetics*
  • Cystic Fibrosis Transmembrane Conductance Regulator
  • Diarrhea / microbiology*
  • Diarrhea / mortality
  • Enterotoxins / physiology*
  • Escherichia coli Infections / physiopathology*
  • Genetic Predisposition to Disease
  • Heterozygote*
  • Humans
  • Membrane Proteins / genetics
  • Membrane Proteins / physiology*
  • Models, Biological
  • Selection, Genetic
  • White People / genetics*

Substances

  • CFTR protein, human
  • Chlorides
  • Enterotoxins
  • Membrane Proteins
  • Cystic Fibrosis Transmembrane Conductance Regulator