Sequence of DNA replication in 277 R- and Q-bands of human chromosomes using a BrdU treatment

Chromosoma. 1976 Oct 12;58(1):51-61. doi: 10.1007/BF00293440.

Abstract

Replication times for all important chromosome bands, of both types R and Q (277 structures) are analysed. The R-bands form a group of structures whose DNA replicates during the early S-phase, while the DNA situated in the Q-bands replicates during the late S-phase. There may not exist overlapping between replication times of these two types of structures. The widest R-bands are those which are the earliest to replicate; in general, the most intense Q-bands are those which are the latest to replicate. Especially among these last ones, a certain asynchronism exists between the replication times. Finally the heterochromatin of chromosomes 1, 16 and Y and of the short arms of the acrocentrics could contain two types of DNA which replicate at different times.

MeSH terms

  • Bromodeoxyuridine
  • Chromosomes / metabolism*
  • DNA Replication*
  • Heterochromatin / metabolism
  • Humans
  • Mitosis
  • Quinacrine
  • Staining and Labeling
  • Time Factors

Substances

  • Heterochromatin
  • Bromodeoxyuridine
  • Quinacrine