Camurati-Engelmann's syndrome is a rare congenital disease characterised by hyperostosis and sclerosis with a predilection for the long bones of the lower limbs. The authors report a case in an adult with a family history of the disease, and multiple localisations in the diaphyses of the long bones. The site of pain and greatest involvement of the disease was the right tibia and fibula. The affection was treated by drilling and reaming the medullary canal with drills of increasing diameter. This method is easy to carry out, causes little trauma, and has undoubted advantages in greatly reducing the period of bedrest and aiding functional recovery.