Genetic and non-genetic determinants of outcomes in cystic fibrosis

Linda L Wolfenden; Michael S Schechter

doi:10.1016/j.prrv.2008.04.002

Genetic and non-genetic determinants of outcomes in cystic fibrosis

Paediatr Respir Rev. 2009 Mar;10(1):32-6. doi: 10.1016/j.prrv.2008.04.002. Epub 2008 Aug 3.

Authors

Linda L Wolfenden¹, Michael S Schechter

Affiliation

¹ Emory Cystic Fibrosis Center, Emory University, Atlanta, Georgia, USA. Lindy.Wolfenden@emoryhealthcare.org

PMID: 19203742
DOI: 10.1016/j.prrv.2008.04.002

Abstract

The treatment of cystic fibrosis has improved significantly over the past three decades. Median survival has improved by decades and is now estimated to be 37 years. Many factors contribute to improvements in disease severity and outcome. This paper reviews the current evidence of three groups of important factors: genetic, environmental and healthcare related.

Publication types

Review

MeSH terms

Cystic Fibrosis / genetics*
Cystic Fibrosis / therapy*
Environmental Exposure*
Humans
Severity of Illness Index
Socioeconomic Factors
Tobacco Smoke Pollution / adverse effects
Treatment Outcome

Substances

Tobacco Smoke Pollution