LINE drive. retrotransposition and genome instability

Haig H Kazazian Jr; John L Goodier

doi:10.1016/s0092-8674(02)00868-1

LINE drive. retrotransposition and genome instability

Cell. 2002 Aug 9;110(3):277-80. doi: 10.1016/s0092-8674(02)00868-1.

Authors

Haig H Kazazian Jr¹, John L Goodier

Affiliation

¹ Department of Genetics, School of Medicine, 475 Clinical Research Building, 415 Curie Boulevard, University of Pennsylvania, Philadelphia 19105, USA. kazazian@mail.med.upenn.edu

PMID: 12176313
DOI: 10.1016/s0092-8674(02)00868-1

Abstract

The LINE-1 (L1) retrotransposon, the most important human mobile element, shapes the genome in many ways. Now two groups provide evidence that L1 retrotransposition is associated with large genomic deletions and inversions in transformed cells. If these events occur at a similar frequency in vivo, they have had a substantial effect on human genome evolution.

Publication types

Comment
Review

MeSH terms

Animals
Capsid / genetics
Capsid Proteins*
Evolution, Molecular*
Gene Deletion*
Genome, Human*
Glycoproteins / genetics
Humans
Long Interspersed Nucleotide Elements / genetics*
Mice
Mutagenesis, Site-Directed / genetics
Mutation / genetics*
Polymorphism, Genetic / genetics*
Retroelements / genetics*

Substances

Capsid Proteins
Glycoproteins
Retroelements