Major recessive gene(s) with considerable residual polygenic effect regulating adult height: confirmation of genomewide scan results for chromosomes 6, 9, and 12

Am J Hum Genet. 2002 Sep;71(3):646-50. doi: 10.1086/342216. Epub 2002 Jul 15.

Abstract

Segregation and linkage analyses were performed for adult height in a population of 200 Dutch families, each of which was ascertained through a proband with asthma. The best-fit model from the segregation analysis was a major recessive gene with a significant residual polygenic background. Models without a polygenic component were rejected. A genomewide scan was performed, and it confirmed previous linkage results for chromosomes 6q25 (LOD = 3.06, D6S2436), 9p1 (LOD = 2.09, D9S301), and 12q1 (LOD = 1.86, D12S375). Our results provide evidence that a combination of segregation and linkage approaches is valuable in understanding genetic determination of common complex traits.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aging
  • Body Height / genetics*
  • Chromosome Mapping*
  • Chromosomes, Human, Pair 12 / genetics*
  • Chromosomes, Human, Pair 6 / genetics*
  • Chromosomes, Human, Pair 9 / genetics*
  • Female
  • Gene Frequency
  • Genes, Recessive / genetics*
  • Genome, Human
  • Humans
  • Lod Score
  • Male
  • Models, Genetic
  • Multifactorial Inheritance / genetics*
  • Netherlands
  • Sex Characteristics