Abstract
A predisposition to tumor development is currently associated with some, but not all, constitutional chromosomal abnormalities. In a series of 578 children, in which conventional cytogenetic investigation was performed on material from various benign and malignant tumors, four boys and one girl were also found to have constitutional balanced chromosomal rearrangements. The figure of 5 in 578 is notable because the reported incidence of balanced rearrangements in newborns is approximately 1 in 450. Thereby suggesting that some, if not all, children with balanced constitutional chromosomal rearrangements have an increased predisposition for neoplasms developing.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Abnormalities, Multiple / genetics
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Adolescent
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Aneuploidy
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Child
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Child, Preschool
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Chromosome Aberrations*
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Chromosome Disorders / complications
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Chromosome Disorders / epidemiology
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Chromosome Disorders / genetics
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Chromosomes, Human / ultrastructure*
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Female
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Genes, Tumor Suppressor
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Genetic Predisposition to Disease
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Humans
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Infant
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Karyotyping
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Kidney Neoplasms / genetics
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Leukemia / epidemiology
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Leukemia / genetics
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Lymphoma / epidemiology
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Lymphoma / genetics
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Male
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Neoplasms / epidemiology
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Neoplasms / genetics*
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Nephroma, Mesoblastic / genetics
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
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Retrospective Studies
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Rhabdomyosarcoma, Embryonal / genetics
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Risk
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Translocation, Genetic
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Wilms Tumor / genetics
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Xanthogranuloma, Juvenile / genetics