Abstract
In this study we describe cloning and expression of CSAL2, a second member of the spalt gene family in chick. All spalt proteins are characterized by the presence of multiple zinc-finger motifs, which are highly conserved. Mutations in HSAL1, a human spalt gene result in Townes-Brocks syndrome (TBS). We show here that CSAL2 is expressed in many of the tissues affected in TBS, including neural tissue, limb buds, mesonephros and cloaca.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Central Nervous System / embryology
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Chick Embryo
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Cloning, Molecular
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Extremities / embryology
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Homeodomain Proteins / biosynthesis*
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Homeodomain Proteins / chemistry
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Homeodomain Proteins / genetics*
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Humans
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Mice
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Molecular Sequence Data
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Mutation
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Phylogeny
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Reverse Transcriptase Polymerase Chain Reaction
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Sequence Homology, Amino Acid
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Tail / embryology
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Transcription Factors / biosynthesis*
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Transcription Factors / chemistry
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Transcription Factors / genetics*
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Xenopus
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Xenopus Proteins*
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Zinc Fingers
Substances
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Homeodomain Proteins
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Sall3 protein, mouse
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Transcription Factors
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Xenopus Proteins
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sal1-A protein, Xenopus
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spalt protein, vertebrate