Abstract
Alzheimer's disease is a debilitating neurodegenerative disorder that afflicts an increasing part of our ageing population. An isoform of apolipoprotein E, a protein that mediates the transport of lipids and cholesterol in the circulatory system, predisposes carriers of this allele to the common late-onset form of the disease. How this protein is related to a neurodegenerative disorder is an enigma. Mounting evidence indicates that apolipoprotein E receptors, which are abundantly expressed in most neurons in the central nervous system, also fulfill critical functions during brain development and may profoundly influence the pathogenesis of Alzheimer's disease.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Alzheimer Disease / genetics*
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Amyloid beta-Peptides / physiology
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Amyloid beta-Protein Precursor / physiology*
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Animals
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Apolipoproteins E / physiology
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Brain / growth & development*
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Humans
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Low Density Lipoprotein Receptor-Related Protein-1
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Peptide Fragments / physiology
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Receptors, LDL / physiology*
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Receptors, Lipoprotein / physiology*
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tau Proteins / physiology
Substances
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Amyloid beta-Peptides
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Amyloid beta-Protein Precursor
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Apolipoproteins E
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Low Density Lipoprotein Receptor-Related Protein-1
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Peptide Fragments
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Receptors, LDL
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Receptors, Lipoprotein
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amyloid beta-protein (29-40)
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tau Proteins