A rare case of acromegaly associated with pachydermoperiostosis

C Shimizu; M Kubo; H Kijima; R Uematsu; Y Sawamura; A Ishizu; T Koike

doi:10.1007/BF03343577

A rare case of acromegaly associated with pachydermoperiostosis

J Endocrinol Invest. 1999 May;22(5):386-9. doi: 10.1007/BF03343577.

Authors

C Shimizu¹, M Kubo, H Kijima, R Uematsu, Y Sawamura, A Ishizu, T Koike

Affiliation

¹ Department of Medicine II, Hokkaido University School of Medicine, Sapporo, Japan. cshimizu@med.hokudai.ac.jp

PMID: 10401713
DOI: 10.1007/BF03343577

Abstract

Pachydermoperiostosis (PDP) is a rare syndrome manifested clinically by finger clubbing, extremity enlargement, hypertrophic skin changes, and periosteal bone formation. The pathogenesis of the disorder has not been clarified and few endocrine abnormalities were apparent. We report here a 58-year-old man with acromegaly associated with PDP, the features of clubbed fingers, coarse skin, and cutis verticis gyrata. Acromegaly due to GH-producing pituitary adenoma was confirmed in endocrinological and pathological studies.

Publication types

Case Reports

MeSH terms

Acromegaly / complications*
Acromegaly / diagnosis
Acromegaly / etiology
Adenoma / complications
Adenoma / diagnosis
Adenoma / surgery
Glucose Tolerance Test
Human Growth Hormone / biosynthesis
Human Growth Hormone / blood
Humans
Insulin-Like Growth Factor I / analysis
Male
Middle Aged
Osteoarthropathy, Primary Hypertrophic / complications*
Osteoarthropathy, Primary Hypertrophic / diagnosis
Pituitary Neoplasms / complications
Pituitary Neoplasms / diagnosis
Pituitary Neoplasms / surgery
Thyrotropin-Releasing Hormone

Substances

Human Growth Hormone
Thyrotropin-Releasing Hormone
Insulin-Like Growth Factor I