Acute Remodeling of Parenchyma in Pulmonary and Extrapulmonary ARDS. An Autopsy Study of Collagen-Elastic System Fibers
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38 - Acute Respiratory Distress Syndrome
2019, Kendig's Disorders of the Respiratory Tract in ChildrenClinical and biological heterogeneity in acute respiratory distress syndrome: Direct versus indirect lung injury
2014, Clinics in Chest MedicineCitation Excerpt :One retrospective study showed that direct ARDS had significantly more alveolar collapse, fibrin deposition, and alveolar wall edema than ARDS from indirect causes.7 Increased amounts of collagen, but not elastin, were present in early ARDS from direct injury but not in ARDS from indirect injury.8 Lamy and colleagues9 demonstrated that patients with limited response to positive end-expiratory pressure (PEEP) had more severe tissue injury with greater alveolar hemorrhage and exudate on lung biopsy.
A model of surfactant-induced surface tension effects on the parenchymal tethering of pulmonary airways
2013, Journal of BiomechanicsCitation Excerpt :Since the surfactant function is reduced in ARDS, our parenchyma model is reasonably able to simulate the early stage of ARDS. We also investigated the effect of increasing the amount of collagen fiber simulating lung fibrosis (Negri et al., 2002). When the amount of collagen is increased, Fig. 5 shows that the pressure–volume curve becomes nearly linear and the volume at a fixed pressure is decreased because of an increase of apparent stiffness.
Acute Respiratory Distress Syndrome
2012, Kendig and Chernick's Disorders of the Respiratory Tract in ChildrenEffects of inhaled nitric oxide and surfactant with extracorporeal life support in recovery phase of septic acute lung injury in piglets
2010, Pulmonary Pharmacology and TherapeuticsCitation Excerpt :We used young piglets for aggressive respiratory treatment in order to better compare with clinical conditions and obtain longer period of recovery from ALI. Furthermore, Negri and coworkers found that collagen content was greater in patients with pulmonary ARDS than in extrapulmonary ARDS [37]. Accordingly, extrapulmonary ALI model in our study may be another reason that results in different outcome on pulmonary fibrosis compared with pulmonary ALI model in Hagiwara's study.
Pressure- and time-dependent alveolar recruitment/derecruitment in a spatially resolved patient-specific computational model for injured human lungs
2024, International Journal for Numerical Methods in Biomedical Engineering
This study was supported by the following Brazilian agencies: the National Council for Scientific and Technological Development (CNPq), Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) and Instituto dos Laboratórios de Investigação Médica (LIMs) HCFMUSP