Identification of centaurin-α2: a phosphatidylinositide-binding protein present in fat, heart and skeletal muscle
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Elevated Expression of ADAP2 is Associated With Aggressive Behavior of Human Clear-Cell Renal Cell Carcinoma and Poor Patient Survival
2023, Clinical Genitourinary CancerCitation Excerpt :It concentrates at the plasma membrane in unstimulated cells, and it releases from the membrane upon the addition of wortmannin, which inhibits PI3-kinase.11 Centaurin-α2 specifically binds the phosphatidylinositol (PI)3-kinase lipid products PI3,4-P2 and PI 3,4,5-P3 (PIP3) through its C-terminal PH domain13 and binds IP4 with high affinity at the PH-N domain.11 Both PIP3 and PI 3,4-P2 play major roles as second messengers in many cellular functions, such as cell migration and vesicle budding.13
Modulation of Monomeric G Proteins by Phosphoinositides
2009, Handbook of Cell Signaling, Second EditionThe Arf6 GAP centaurin α-1 is a neurolonal actin-binding protein which also functions via GAP-independent activity to regulate te actin cytoskeleton
2004, European Journal of Cell BiologyPhosphoinositide signaling: From affinity probes to pharmaceutical targets
2004, Chemistry and BiologyArf GAPs: Multifunctional proteins that regulate membrane traffic and actin remodelling
2004, Cellular SignallingADAP1 limits neonatal cardiomyocyte hypertrophy by reducing integrin cell surface expression
2018, Scientific Reports
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