Mechanisms of AllergyThe IL1A genotype associates with atopy in nonasthmatic adults☆,☆☆
Section snippets
Methods
Asthmatic patients and control subjects were participants in a Finnish population-based case-control study aimed at identifying risk factors and predictors of the outcome of adult asthma. Inclusion criteria for asthmatic subjects were age over 30 years and entitlement to special reimbursement for asthma medication from the Social Insurance Institution of Finland. The entitlement is granted if the criteria for persistent asthma are fulfilled, as certified by a chest specialist. Typical history,
Skin prick testing
In the asthmatic group there were more subjects with positive skin test responses among the female population than among the male population (62.0% vs 47.3%; P = .025, χ2 testing, df = 1). However, the number of positive skin test reactions was similar in patients of both sexes. In the control group the percentage of subjects with positive skin test responses was 38.9% in female subjects and 37.3% in male subjects (P = .756, χ2 testing, df = 1). As in the case of asthmatic patients, no
IL1A genotype
The IL1A genotype distribution was similar in the asthmatic and control groups (Table III). This was also the case when the sexes were analyzed separately (data not shown).
There was no significant association between IL1A genotype and skin test results in asthmatic patients. In the control subjects, on the other hand, the data obtained showed that the IL1A genotype distribution was significantly different between the individuals with positive (≥1 positive reactions) and negative skin test
Discussion
Our study was conducted to assess skin test findings in a population-based sample of adult asthmatic patients and control subjects and to establish whether the IL1A genotype affects allergy testing. We have previously shown that the IL1B gene carries asthma susceptibility in male subjects.10 The IL1A genotype distribution in the asthmatic and control groups was similar, and therefore no contribution to asthma susceptibility was observed.
As expected, atopy was more common among asthmatic
References (28)
Biologic basis for interleukin-1 in disease
Blood
(1996)- et al.
Induction and localization of cutaneous interleukin-1 beta mRNA during contact sensitization
Toxicol Appl Pharmacol
(2000) - et al.
The IL-1beta genotype carries asthma susceptibility only in men
J Allergy Clin Immunol
(2002) - et al.
An analysis of linkage disequilibrium in the interleukin-1 gene cluster, using a novel grouping method for multiallelic markers
Am J Hum Genet
(1998) - et al.
Allergen skin-test reactivity in a community population sample: correlation with age, histamine skin reactions and total serum immunoglobulin E
J Allergy Clin Immunol
(1981) - et al.
Chronologic aging alters the response to ultraviolet-induced inflammation in human skin
J Invest Dermatol
(1982) - et al.
Changes in skin and nasal sensitivity to allergens and the course of rhinitis; a long-term follow-up study
Ann Allergy Asthma Immunol
(1999) - et al.
Association of asthma with serum IgE levels and skin-test reactivity to allergens
N Engl J Med
(1989) - et al.
Respiratory disorders and allergy skin-test reactions
Ann Intern Med
(1976) - et al.
Skin test reactivity to common aeroallergens and decline of lung function. The Normative Aging Study
Am J Respir Crit Care Med
(1996)
Allergy markers in respiratory epidemiology
Eur Respir J
Skin prick test reactivity to common aeroallergens in relation to total IgE, respiratory symptoms, and smoking in a general population sample of northern Italy
Allergy
Transcriptional regulation of intracellular IL-1 receptor antagonist gene by IL-1 alpha in primary mouse keratinocytes
J Immunol
Asthma
N Engl J Med
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Supported by Rehabilitation Funds of the Finnish Social Insurance Institution, the Medical Research Fund of Tampere University Hospital, and the Tampere Tuberculosis Foundation.
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Reprint requests: Jussi Karjalainen, MD, University of Tampere, Medical School, FIN-33014 University of Tampere, Finland.