Exp Clin Endocrinol Diabetes 2004; 112(5): 253-257
DOI: 10.1055/s-2004-817972
Article

J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

The Gly482Ser Variant in the Peroxisome Proliferator-Activated Receptor γ Coactivator-1 is not Associated with Diabetes-Related Traits in Non-Diabetic German and Dutch Populations

M. Stumvoll1 , A. Fritsche1 , L. M. t'Hart3 , J. Machann2 , C. Thamer1 , O. Tschritter1 , T. W. Van Haeften5 , S. Jacob1 , J. M. Dekker4 , J. A. Maassen3 , 4 , F. Machicao1 , F. Schick2 , R. J. Heine4 , H. Häring1
  • 1Department of Endocrinology, Metabolism and Pathobiochemistry, University of Tübingen, Germany
  • 2Section of Experimental Radiology, Department of Diagnostic Radiology, University of Tübingen, Germany
  • 3Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
  • 4(on behalf of the Hoorn Study) Institute for Research in Extramural Medicine, Free University Medical Center, Amsterdam, The Netherlands
  • 5Department of Internal Medicine, University Medical Center, Utrecht, The Netherlands
Further Information

Publication History

Received: March 3, 2003 First decision: May 14, 2003

Accepted: October 6, 2003

Publication Date:
14 May 2004 (online)

Abstract

The peroxisome proliferator-activated receptor γ coactivator-1 (PGC-1) is involved in regulation of fatty acid oxidation, skeletal muscle fiber type specificity, and gluconeogenesis. The prevalent Gly482Ser variant in PGC-1 was shown to be associated with type 2 diabetes in some but not all studies. Moreover, it is unclear whether it influences prediabetic subphenotypes in non-diabetic populations. We studied the association of this variant with glucose tolerance (oral glucose tolerance test), insulin sensitivity (euglycemic hyperinsulinemic clamp) of glucose disposal and antilipolysis, insulin secretion (hyperglycemic clamp, 10 mM), maximal oxygen consumption (VO2max, bicycle ergometry), and intramyocellular lipids (magnetic resonance spectroscopy, tibialis and soleus muscle) in a normal glucose tolerant German cohort (n = 423) and a normal (n = 65) and impaired glucose tolerant (n = 94) cohort from the Netherlands. No statistically significant association with an examined phenotype was detected in any of the study cohorts. Specifically, VO2max and the soleus-to-tibialis ratio of intramyocellular lipid contents as a surrogate parameter of fiber type specificity was not different between the genotype groups. We conclude, that the Gly482Ser variant in PGC-1 is not associated with diabetes-related traits or skeletal muscle fiber type composition in a non-diabetic German and Dutch population.

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Dr. Michael Stumvoll

Universitätsklinikum Leipzig · Medizinische Klinik II

Philipp-Rosenthal-Satraße 27

04301 Leipzig

Germany

Phone: + 493419713380

Fax: + 49 34 19 71 33 89

Email: michael.stumvoll@medizin.uni-leipzig.de

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