Cell type-specific desmosomal plaque proteins of the plakoglobin family: plakophilin 1 (band 6 protein)
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2016, Biochimica et Biophysica Acta - General SubjectsNuclear signaling from cadherin adhesion complexes
2015, Current Topics in Developmental BiologyCitation Excerpt :The plakophilin-catenin subfamily may also prove to engage in such nuclear signaling via small-GTPase effects. Although we do not discuss the plakophilins in depth, they are structurally similar to the other armadillo-domain-containing catenins and were first found in association with desmosomal cadherins (desmogleins and desmocollins) (Heid et al., 1994; reviewed in Bass-Zubek et al., 2009). p120ctn further engages in modulation of NFκB, a pathway having clear links to the nucleus.
Plakophilin-1 localizes to the nucleus and interacts with single-stranded DNA
2010, Journal of Investigative DermatologyDesmosomal plakophilins in the prostate and prostatic adenocarcinomas: Implications for diagnosis and tumor progression
2010, American Journal of PathologyCitation Excerpt :Thereby, we noticed a strong staining of the glandular epithelium for all members of the p120 subfamily with the exception of neurojungin (data not shown). According to previous reports,2,5,11,13 the occurrence of all three plakophilins in the glandular epithelium of the prostate, especially of PKP1, was unexpected, and therefore, we followed this observation in more detail. We compared the localization PKP1-3 with that of other desmosomal plaque proteins (eg, desmoplakin) and desmosomal transmembrane proteins (eg, desmoglein) and found for all three plakophilins colocalization with desmosomal marker proteins (Figure 1).
Plakophilins: multifunctional scaffolds for adhesion and signaling
2009, Current Opinion in Cell BiologyCitation Excerpt :The three PKPs exhibit differential but overlapping tissue distribution patterns. PKP1 is found in the desmosomes of differentiated layers of stratified epithelia [5–7]. PKP2 is expressed in all simple, complex and stratified epithelia as well as cardiac myocytes (where it is the only PKP expressed), germinal centers of lymph node follicles, a variety of tumors, and numerous cell lines [8,9].
A δ-catenin signaling pathway leading to dendritic protrusions
2008, Journal of Biological Chemistry