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  • Oncogenomics
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Linkage disequilibrium mapping of novel lung tumor susceptibility quantitative trait loci in mice

Oncogene volume 21, pages 6858–6865 (2002)Cite this article

Abstract

Linkage disequilibrium (LD) has been used to map chromosomal regions regulating quantitative traits, also called quantitative trait loci (QTLs). With the increasing number of available mouse polymorphic genetic markers, LD can be estimated for the purpose of fine-mapping a given QTL or in the identification of novel QTLs. A whole-genome LD analysis was conducted for mapping mouse lung tumor susceptibility QTLs in 25 strains of mice with known susceptibility to lung cancer using 5638 genetic markers. A total of 63 markers were found to be significantly associated with lung tumor susceptibility, many of which were novel QTLs. This study demonstrates the feasibility of using LD to map QTLs on a whole genome level. Further characterization of the newly identified lung tumor susceptibility QTLs may lead to the identification of genes whose human homologue may predispose some individuals to lung cancer.

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Acknowledgements

We thank MRW Festing for his help in providing valuable information on genetic markers. We are grateful to A de la Chapelle and G Stoner for their critical reading of this manuscript and helpful discussions. This work was supported by NIH grants R01CA58554, R01CA78797 & P30CA16058.

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  1. Division of Human Cancer Genetics, The Ohio State University Comprehensive Cancer, 514 Medical Research Facility, 420 West 12th Avenue, Columbus, 43210, Ohio, OH, USA

    Daolong Wang, William J Lemon & Ming You

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  1. Daolong Wang
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  2. William J Lemon
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Correspondence to Ming You.

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Wang, D., Lemon, W. & You, M. Linkage disequilibrium mapping of novel lung tumor susceptibility quantitative trait loci in mice. Oncogene 21, 6858–6865 (2002). https://doi.org/10.1038/sj.onc.1205886

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