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  • Original Paper
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Twenty years of p53 research: structural and functional aspects of the p53 protein

A Corrigendum to this article was published on 29 March 2000

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References

  • Abarzua P, Lo Sardo JE, Gubler ML, Spathis R, Lu YA, Felix A and Neri A. . 1996 Oncogene 13: 2477–2482.

  • Agarwal ML, Agarwal A, Taylor WR and Stark GR. . 1995 Proc. Natl. Acad. Sci. USA 92: 8493–8497.

  • Agoff SN, Hou J, Linzer DI and Wu B. . 1993 Science 259: 84–87.

  • Almog N and Rotter V. . 1997 Biochim. Biophys. Acta 1333: F1–F27.

  • An WG, Kanekal M, Simon MC, Maltepe E, Blagosklonny MV and Neckeres LM. . 1998 Nature 392: 405–408.

  • Anderson ME, Woelker B, Reed M, Wang P and Tegtmeyer P. . 1997 Mol. Cell. Biol. 17: 6255–6264.

  • Angelopoulou K, Diamandis EP, Sutherland DJ, Kellen JA and Bunting PS. . 1994 Int. J. Cancer 58: 480–487.

  • Attardi LD, Lowe SW, Brugarolas J and Jacks T. . 1996 EMBO J. 15: 3693–3701.

  • Avantaggiati ML, Ogryzko V, Gardner K, Giordano A, Levine AS and Kelly K. . 1997 Cell 89: 1175–1184.

  • Bakalkin G, Yakovleva T, Selivanova G, Magnusson KP, Szekely L, Kiseleva E, Klein G, Terenius L and Wiman KG. . 1994 Proc. Natl. Acad. Sci. USA 91: 413–417.

  • Baker SJ, Fearon ER, Nigro JM, Hamilton SR, Preisinger AC, Jessup JM, vanTuinen P, Ledbetter DH, Barker DF and Nakamura Y. . 1989 Science 244: 217–221.

  • Baker SJ, Markowitz S, Fearon ER, Willson JK and Vogelstein B. . 1990 Science 249: 912–915.

  • Banin S, Moyal L, Shiel SY, Taya Y, Anderson CW, Chessa L, Smorodinsky NI, Prives C, Reiss Y, Shiloh Y and Ziv Y. . 1998 Science 281: 1674–1677.

  • Bargonetti J, Friedman PN, Kern SE, Vogelstein B and Prives C. . 1991 Cell 65: 1083–1091.

  • Bargonetti J, Manfredi JJ, Chen X, Marshak DR and Prives C. . 1993 Genes Dev. 7: 2565–2574.

  • Baserga R. . 1994 Cell 79: 927–930.

  • Bates S, Phillips AC, Clark PA, Stott F, Peters G, Ludwig RL and Vousden KH. . 1998 Nature 395: 124–125.

  • Beaudry GA, Bertelsen AH and Sherman MI. . 1996 Curr. Opin. Biotechnol. 7: 592–600.

  • Bellamy COC, Prost S, Wyllie AH and Harrison DJ. . 1997 J. Pathol. 193: 177–181.

  • Ben David Y, Prideaux VR, Chow V, Benchimol S and Bernstein A. . 1988 Oncogene 3: 179–185.

  • Benchimol S, Lamb P, Crawford LV, Sheer D, Shows TB, Bruns GA and Peacock J. . 1985 Somat. Cell Mol. Genet. 11: 505–510.

  • Bennett WP, Hussain SP, Vahakangas KH, Khan MA, Shields PG and Harris CC. . 1999 J. Pathol. 187: 8–18.

  • Bouck N. . 1996 Biochim. Biophys. Acta 1287: 63–66.

  • Bourdon JC, Deguin-Chambon V, Lelong JC, Dessen P, May P, Debuire B and May E. . 1997 Oncogene 14: 85–94.

  • Brain R and Jenkins JR. . 1994 Oncogene 9: 1775–1780.

  • Braithwaite AW, Sturzbecher HW, Addison C, Palmer C, Rudge K and Jenkins JR. . 1987 Nature 329: 458–460.

  • Brash DE, Rudolph JA, Simon JA, Lin A, McKenna GJ, Baden HP, Halperin AJ and Ponten J. . 1991 Proc. Natl. Acad. Sci. USA 88: 10124–10128.

  • Bressac B, Kew M, Wands J and Ozturk M. . 1991 Nature 350: 429–431.

  • Brugarolas J, Chandrasekaran C, Gordon JI, Beach D, Jacks T and Hannon GI. . 1995 Nature 377: 552–557.

  • Buchhop S, Gibson MK, Wang XW, Wagner P, Sturzbecher HW and Harris CC. . 1997 Nucleic Acids Res. 25: 3868–3874.

  • Buckbinder L, Talbott R, Velascomiguel S, Takenaka I, Faha B, Seizinger BR and Kley N. . 1995 Nature 377: 646–649.

  • Caelles C, Helmberg A and Karin M. . 1994 Nature 370: 220–223.

  • Canman CE and Kastan MB. . 1997 Adv. Pharmacol. 41: 429–460.

  • Canman CE, Lim DS, Cimprich KA, Yaya Y, Tamai K, Sakaguchi K, Appella E, Kastan M and Siliciano JD. . 1998 Science 281: 1677–1679.

  • Caron de Fromentel C, May-Levin F, Mouriesse H, Lemerle J, Chandrasekaran K and May P. . 1987 Int. J. Cancer 39: 185–189.

  • Caron de Fromentel C and Soussi T. . 1992 Genes Chromosomes Cancer 4: 1–15.

  • Chang C, Simmons DT, Martin MA and Mora PT. . 1979 J. Virol. 31: 463–471.

  • Chen PL, Chen YM, Bookstein R and Lee WH. . 1990 Science 250: 1576–1580.

  • Chen X, Ko LJ, Jayaraman L and Prives C. . 1996 Genes Dev. 10: 2438–2451.

  • Chernov MV, Ramana CV, Adler VV and Stark GR. . 1998 Proc. Natl. Acad. Sci. USA 95: 2284–2289.

  • Chernov MV and Stark GR. . 1997 Oncogene 14: 2503–2510.

  • Chin L, Pomerantz J and Depinho RA. . 1998 Trends Biochem. Sci. 23: 291–296.

  • Cho YJ, Gorina S, Jeffrey PD and Pavletich NP. . 1994 Science 265: 346–355.

  • Chow V, Ben David Y, Bernstein A, Benchimol S and Mowat M. . 1987 J. Virol. 61: 2777–2781.

  • Clarke AR, Gledhill S, Hooper ML, Bird CC and Wyllie AH. . 1994 Oncogene 9: 1767–1773.

  • Clarke AR, Purdie CA, Harrison DJ, Morris RG, Bird CC, Hooper ML and Willie AH. . 1993 Nature 362: 849–852.

  • Clore GM, Omichinski JG, Sakaguchi K, Zambrano N, Sakamoto H, Appella E and Gronenborn AM. . 1994 Science 265: 386–391.

  • Clore GM, Omichinski JG, Sakaguchi K, Zambrano N, Sakamoto H, Appella E and Gronenborn AM. . 1995 Science 267: 1515–1516.

  • Cook A and Milner J. . 1990 Br. J. Cancer 61: 548–552.

  • Crawford L, Leppard K, Lane D and Harlow E. . 1982 J. Virol. 42: 612–620.

  • Cross SM, Sanchez CA, Morgan CA, Schmike MK, Ramel S, Idzerda RL, Raskind WH and Reid BJ. . 1995 Science 267: 1353–1356.

  • Dang CV and Lee WM. . 1989 J. Biol. Chem. 264: 18019–18023.

  • David-Pfeuty T, Chakrani F, Ory K and Nouvian Dooghe Y. . 1996 Cell Growth Differ. 7: 1211–1225.

  • Degregori J, Kowalik T and Nevins JR. . 1995a Mol. Cell. Biol. 15: 4215–4224.

  • Degregori J, Leone G, Ohtani K, Miron A and Nevins JR. . 1995b Genes Dev. 9: 2873–2887.

  • Deleo AB, Jay G, Appella E, Dubois GC, Law LW and Old LJ. . 1979 Proc. Natl. Acad. Sci. USA 76: 2420–2424.

  • Deng CX, Zhang PM, Harper JW, Elledge SJ and Leder P. . 1995 Cell 82: 675–684.

  • Di Leonardo A, Linke SP, Clarkin K and Wahl GM. . 1994 Genes Dev. 8: 2540–2551.

  • Diller L, Kassel J, Nelson CE, Gryka MA, Litwak M, Gebhardt M, Bressac B, Ozturk M, Baker SJ, Vogelstein B and Friend SH. . 1990 Mol. Cell. Biol. 10: 5772–5782.

  • Dittmer D, Pati S, Zambetti G, Chu S, Teresky AK, Moore AM, Finlay C and Levine AJ. . 1993 Nat. Genet. 4: 42–46.

  • Donehower LA, Harvey M, Slagle BL, Mcarthur MJ, Mongomery Jr CA, Butel JS and Bradley A. . 1992 Nature 356: 215–221.

  • Dutta A, Ruppert JM, Aster JC and Winchester E. . 1993 Nature 365: 79–82.

  • Ehrhart JC, Duthu A, Ullrich S, Appella E and May P. . 1988 Oncogene 3: 595–603.

  • El-Deiry WS, Kern SE, Pietenpol JA, Kinzler KW and Vogelstein B. . 1992 Nat. Genet. 1: 45–49.

  • El-Deiry WS, Tokino T, Velculescu VE, Levy DL, Parsons R, Trent JM, Lin D, Mercer WE, Kinzer KW and Vogelstein B. . 1993 Cell 75: 817–825.

  • Eliyahu D, Michalovitz D, Eliyahu S, Pinhasi-Kimhi O and Oren M. . 1989 Proc. Natl. Acad. Sci. USA 86: 8763–8767.

  • Eliyahu D, Raz A, Gruss P, Givol D and Oren M. . 1984 Nature 312: 646–649.

  • Fields S and Jang JA. . 1990 Science 249: 1046–1049.

  • Finlay CA, Hinds PW and Levine AJ. . 1989 Cell 57: 1083–1093.

  • Fiscella M, Zambrano N, Ullrich SJ, Unger T, Lin D, Cho B, Mercer WE, Anderson CW and Appella E. . 1994 Oncogene 9: 3249–3257.

  • Flores-Rozas H, Kelman Z, Dean FB, Pan ZQ, Harper JW, Elledge SJ, O'Donnell M and Hurwitz J. . 1994 Proc. Natl. Acad. Sci. USA 91: 8655–8659.

  • Ford JM and Hanawalt PC. . 1995 Proc. Natl. Acad. Sci. USA 92: 8876–8880.

  • Funk WD, Pak DT, Karas RH, Wright WE and Shay JW. . 1992 Mol. Cell. Biol. 12: 2866–2871.

  • Gannon JV, Greaves R, Iggo R and Lane DP. . 1990 EMBO J. 9: 1595–1602.

  • Gannon JV and Lane DP. . 1987 Nature 329: 456–458.

  • Giaccia AJ and Kastan MB. . 1998 Genes Dev. 12: 2973–2983.

  • Ginsberg D, Mechta F, Yaniv M and Oren M. . 1991 Proc. Natl. Acad. Sci. USA 88: 9979–9983.

  • Gorina S and Pavletich NP. . 1996 Science 274: 1001–1005.

  • Gu W and Roeder RG. . 1997 Cell 90: 595–606.

  • Hainaut P and Milner J. . 1993a Cancer Res. 53: 4469–4473.

  • Hainaut P and Milner J. . 1993b Cancer Res. 53: 1739–1742.

  • Halazonetis TD and Kandil AN. . 1993 EMBO J. 12: 5057–5064.

  • Han JH, Sabbatini P, Perez D, Rao L, Modha D and White E. . 1996 Genes Dev. 10: 461–477.

  • Hanawalt PC. . 1987 Environ. Health Perspect. 76: 9–14.

  • Harris CC and Hollstein M. . 1993 N. Engl. J. Med. 329: 1318–1327.

  • Harvey M, McArthur MJ, Montgomery CA, Butel JS, Bradley A and Donehower LA. . 1993 Nat. Genet. 5: 225–229.

  • Haupt Y, Maya R, Kazaz A and Oren M. . 1997 Nature 387: 296–299.

  • Haupt Y, Rowan S and Oren M. . 1995b Oncogene 10: 1563–1571.

  • Haupt Y, Rowan S, Shaulian E, Vousden KH and Oren M. . 1995a Genes Dev. 9: 2170–2183.

  • He Z, Brinton BT, Greenblatt J, Hassell JA and Ingles CJ. . 1993 Cell 73: 1223–1232.

  • Hermeking H, Lengauer C, Polyak K, He TC, Zhang L, Thiagalingam S and Kinzler KW. . 1997 Mol. Cell 1: 3–11.

  • Herrmann CP, Kraiss S and Montenarh M. . 1991 Oncogene 6: 877–884.

  • Hinds PW, Finlay CA, Frey AB and Levine AJ. . 1987 Mol. Cell. Biol. 7: 2863–2869.

  • Hollstein M, Rice K, Greenblatt MS, Soussi T, Fuchs R, Sorlie T, Hovig E, Smithsorensen B, Montesano R and Harris CC. . 1994 Nucleic Acids Res. 22: 3551–3555.

  • Hollstein M, Shomer B, Greenblatt M, Soussi T, Hovig E, Montesano R and Harris CC. . 1996 Nucleic Acids Res. 24: 141–146.

  • Horikoshi N, Usheva A, Chen JD, Levine AJ, Weinmann R and Shenk T. . 1995 Mol. Cell. Biol. 15: 227–234.

  • Howes KA, Ransom LN, Papermaster DS, Lasudry JGH, Albert DM and Windle JJ. . 1994 Genes Dev. 8: 1300–1310.

  • Hsu IC, Metcalf RA, Sun T, Welsh JA, Wang NJ and Harris CC. . 1991 Nature 350: 427–428.

  • Huang LC, Clarkin KC and Wahl GM. . 1996 Proc. Natl. Acad. Sci. USA 93: 4827–4832.

  • Hupp TR and Lane DP. . 1994 Curr. Biol. 4: 865–875.

  • Hupp TR and Lane DP. . 1995 J. Biol. Chem. 270: 18165–18174.

  • Hupp TR, Meek DW, Midgley CA and Lane DP. . 1992 Cell 71: 875–886.

  • Hupp TR, Meek DW, Midgley CA and Lane DP. . 1993 Nucleic Acids Res. 21: 3167–3174.

  • Hupp TR, Sparks A and Land DP. . 1995 Cell 83: 237–245.

  • Isobe M, Emanuel BS, Givol D, Oren M and Croce CM. . 1986 Nature 320: 84–85.

  • Israeli D, Tessler E, Haupt Y, Elkeles A, Wilder S, Amson R, Telerman A and Oren M. . 1997 EMBO J. 16: 4384–4392.

  • Iwabuchi K, Bartel PL, Li B, Marraccino R and Fields S. . 1994 Proc. Natl. Acad. Sci. USA 91: 6098–6102.

  • Jacks T, Remington L, Williams BO, Schmitt EM, Halachmi S, Bronson R and Weinberg RA. . 1994 Curr. Biol. 4: 1–7.

  • Jayaraman L, Murthy KG, Zhu C, Curran T, Xanthoudakis S and Prives C. . 1997 Genes Dev. 11: 558–570.

  • Jeffrey PD, Gorina S and Pavletich NP. . 1995 Science 267: 1498–1502.

  • Jenkins JR, Chumakov P, Addison C and Sturzbecher HW. . 1988 J. Virol. 62: 3903–3906.

  • Jenkins JR, Rudge K, Chumakov P and Currie GA. . 1985 Nature 317: 816–818.

  • Jenkins JR, Rudge K and Currie GA. . 1984 Nature 312: 651–654.

  • Kaczmarek L, Oren M and Baserga R. . 1986 Exp. Cell Res. 162: 268–272.

  • Kaelin WG. . 1999 J. Natl. Cancer Inst. 91: 594–598.

  • Kaghad M, Bonnet H, Yang A, Creancier L, Biscan JC, Valent A, Minty A, Chalon P, Lelias JM, Dumont X, Ferrara P, McKeon F and Caput D. . 1997 Cell 90: 809–819.

  • Kastan MB, Onyekwere O, Sidransky D, Vogelstein B and Craig RW. . 1991 Cancer Res. 51: 6304–6311.

  • Kastan MB, Zhan Q, El-Deiry WS, Carrier F, Jacks T, Walsh WV, Plunkett BS, Vogelstein B and Fornace AJ. . 1992 Cell 71: 587–597.

  • Kern SE, Kinzler KW, Bruskin A, Jarosz D, Friedman P, Prives C and Vogelstein B. . 1991 Science 252: 1708–1711.

  • Kessis TD, Slebos RJ, Nelson WG, Kastan MB, Plunkett BS, Han SM, Lorincz AT, Hedrick L and Cho KR. . 1993 Proc. Natl. Acad. Sci. USA 90: 3988–3992.

  • Ko LJ and Prives C. . 1996 Genes Dev. 10: 1054–1072.

  • Kraiss S, Quaiser A, Oren M and Montenarh M. . 1988 J. Virol. 62: 4737–4744.

  • Kress M, May E, Cassingena R and May P. . 1979 J. Virol. 31: 472–483.

  • Kubbutat MH, Jones SN and Vousden KH. . 1997 Nature 387: 299–303.

  • Kubbutat MH, Ludwig RL, Ashcroft M and Vousden KH. . 1998 Mol. Cell. Biol. 18: 5690–5698.

  • Kuerbitz SJ, Plunkett BS, Walsh WV and Kastan MB. . 1992 Proc. Natl. Acad. Sci. USA 89: 7491–7495.

  • Lane D and Crawford L. . 1979 Nature 278: 261–263.

  • Lavigueur A, Maltby V, Mock D, Rossant J, Pawson T and Bernstein A. . 1989 Mol. Cell. Biol. 9: 3982–3991.

  • Lechner MS, Mack DH, Finicle AB, Crook T, Vousden KH and Laimins LA. . 1992 EMBO J. 11: 3045–3052.

  • Levine AJ. . 1997 Cell 88: 323–331.

  • Li G, Mitchell DL, Ho VC, Reed JC and Tron VA. . 1996 Am. J. Pathol. 148: 1113–1123.

  • Li R and Botchan MR. . 1993 Cell 73: 1207–1221.

  • Li R, Waga S, Hannon GJ, Beach D and Stillman B. . 1994 Nature 371: 534–537.

  • Li X and Coffino P. . 1996 J. Virol. 70: 4509–4516.

  • Lill NL, Grossman SR, Ginsberg D, DeCaprio J and Livingston DM. . 1997 Nature 387: 823–827.

  • Lin D, Shields MT, Ullrich SJ, Appella E and Mercer WE. . 1992 Proc. Natl. Acad. Sci. USA 89: 9210–9214.

  • Lin JY, Chen Jd, Elenbaas B and Levine AJ. . 1994 Genes Dev. 8: 1235–1246.

  • Lin YP and Benchimol S. . 1995 Mol. Cell. Biol. 15: 6045–6054.

  • Linzer DIH and Levine AJ. . 1979 Cell 17: 43–52.

  • Lohrum M and Scheidtmann KH. . 1996 Oncogene 13: 2527–2539.

  • Lotem J and Sachs L. . 1993 Blood 82: 1092–1096.

  • Lowe SW, Bodis S, McClatchey A, Remington L, Ruley HE, Fisher DE, Housman DE and Jacks T. . 1994 Science 266: 807–810.

  • Lu H and Levine AJ. . 1995 Proc. Natl. Acad. Sci. USA 92: 5154–5158.

  • Lu X and Lane DP. . 1993 Cell 75: 765–778.

  • Mack DH, Vartikar J, Pipas JM and Laimins LA. . 1993 Nature 363: 281–283.

  • Maheswaran S, Englert C, Benett P, Heinrich G and Haber DA. . 1995 Genes Dev. 9: 2143–2146.

  • Malkin D, Li FP, Strong LC, Fraumeni Jr JF, Nelson CE, Kim DH, Kassel J, Gryka MA, Bischoff FZ and Tainsky MA. . 1990 Science 250: 1233–1238.

  • Maltzman W and Czyzyk L. . 1984 Mol. Cell. Biol. 4: 1689–1694.

  • Marshall CJ. . 1991 Cell 64: 313–326.

  • Mayr GA, Reed M, Wang P, Wang Y, Schwedes JF and Tegtmeyer P. . 1995 Cancer Res. 55: 2410–2417.

  • McBride OW, Merry D and Givol D. . 1986 Proc. Natl. Acad. Sci. USA 83: 130–134.

  • Melero JA, Stitt DT, Mangel WF and Carroll RB. . 1979 Virology 93: 466–480.

  • Mercer WE, Nelson D, Deleo AB, Old LJ and Baserga R. . 1982 Proc. Natl. Acad. Sci. USA 79: 6309–6312.

  • Michalovitz D, Halevy O and Oren M. . 1990 Cell 62: 671–680.

  • Midgley CA and Lane DP. . 1997 Oncogene 15: 1179–1189.

  • Miller C, Mohandas T, Wolf D, Prokocimer M, Rotter V and Koeffler HP. . 1986 Nature 319: 783–784.

  • Milne DM, McKendrick L, Jardine LJ, Deacon E, Lord JM and Meek DW. . 1996 Oncogene 13: 205–211.

  • Milner J. . 1984 Nature 310: 143–145.

  • Milner J, Cook A and Mason J. . 1990 EMBO J. 9: 2885–2889.

  • Milner J, Medcalf EA and Cook AC. . 1991 Mol. Cell. Biol. 11: 12–19.

  • Milner J and Milner S. . 1981 Virology 112: 785–788.

  • Miyashita T, Krajewski S, Krajewska M, Wang HG, Lin HK, Liebermann DA, Hoffman B and Reed JC. . 1994 Oncogene 9: 1799–1805.

  • Miyashita T and Reed JC. . 1995 Cell 80: 293–299.

  • Moll U, Laquaglia M, Benard J and Riou G. . 1995 Proc. Natl. Acad. Sci. USA 92: 4407–4411.

  • Moll U, Ostermeyer AG, Haladay R, Winkfield B, Frazier M and Zambetti G. . 1996 Mol. Cell. Biol. 16: 1126–1137.

  • Moll U, Riou G and Levine AJ. . 1992 Proc. Natl. Acad. Sci. USA 89: 7262–7266.

  • Momand J, Zambetti GP, Olson DC, George D and Levine AJ. . 1992 Cell 69: 1237–1245.

  • Mora PT, Chandrasekaran K and McFarland VW. . 1980 Nature 288: 722–724.

  • Morgenbesser SD, Williams BO, Jacks T and Depinho RA. . 1994 Nature 371: 72–74.

  • Mowat M, Cheng A, Kimura N, Bernstein A and Benchimol S. . 1985 Nature 314: 633–636.

  • Munroe DG, Rovinski B, Bernstein A and Benchimol S. . 1988 Oncogene 2: 621–624.

  • Murphy M, Hinman A and Levine AJ. . 1996 Genes Dev. 10: 2971–2980.

  • Nelson WG and Kastan MB. . 1994 Mol. Cell. Biol. 14: 1815–1823.

  • Nemani M, Linares-Cruz G, Bruzzoni-Giovanelli H, Roperch JP, Tuynder M, Bougueleret L, Cherif D, Medhioub M, Pasturaud P, Alvaro V, der Sarkissan H, Cazes L, Le Paslier D, Le G, Israeli D, Dausset J, Sigaux F, Chumakov I, Oren M, Calvo F, Amson RB, Cohen D and Telerman A. . 1996 Proc. Natl. Acad. Sci. USA 93: 9039–9042.

  • Nigro JM, Baker SJ, Preisinger AC, Jessup JM, Hostetter R, Cleary K, Bigner SH, Davidson N, Baylin S and Devilee P. . 1989 Nature 342: 705–708.

  • Oberosler P, Hloch P, Ramsperger U and Stahl H. . 1993 EMBO J. 12: 2389–2396.

  • Okamoto K and Beach D. . 1994 EMBO J. 13: 4816–4822.

  • Okorokov AL, Ponchel F and Milner J. . 1997 EMBO J. 16: 6008–6017.

  • Oliner JD, Kinzler KW, Meltzer PS, George DL and Vogelstein B. . 1992 Nature 358: 80–83.

  • Oliner JD, Pietenpol JA, Thiagalingam S, Gyuris J, Kinzler KW and Vogelstein B. . 1993 Nature 362: 857–860.

  • Oren M. . 1985 Biochim. Biophys. Acta 823: 67–78.

  • Oren M, Reich NC and Levine AJ. . 1982 Mol. Cell. Biol. 2: 443–449.

  • Owen-Schaub LB, Zhang W, Cusack JC, Angelo LS, Santee SM, Fujiwara T, Roth JA, Deisseroth AB, Zhang WW, Kruzel E and Radinsky R. . 1995 Mol. Cell. Biol. 15: 3032–3040.

  • Pan H and Griep AE. . 1994 Genes Dev. 8: 1285–1299.

  • Papathanasiou MA, Kerr NC, Robbins JH, McBride OW, Alamo Jr I, Barrett SF, Hickson ID and Fornace Jr AJ. . 1991 Mol. Cell. Biol. 11: 1009–1016.

  • Parada LF, Land H, Weinberg RA, Wolf D and Rotter V. . 1984 Nature 312: 649–651.

  • Pavletich NP, Chambers KA and Pabo CO. . 1993 Genes Dev. 7: 2556–2564.

  • Pietenpol JA, Tokino T, Thiagalingam S, Eldeiry WS, Kinzler KW and Vogelstein B. . 1994 Proc. Natl. Acad. Sci. USA 91: 1998–2002.

  • Pinhasi-Kimhi O, Michalovitz D, Ben Zeev A and Oren M. . 1986 Nature 320: 182–184.

  • Polyak K, Xia Y, Zweier JL, Kinzler KW and Vogelstein B. . 1997 Nature 389: 300–305.

  • Purdie CA, Harrison DJ, Peter A, Dobbie L, White S, Howie SEM, Salter DM, Bird CC, Wyllie AH, Hooper ML and Clarke AR. . 1994 Oncogene 9: 603–609.

  • Ragimov N, Krauskopf A, Navot N, Rotter V, Oren M and Aloni Y. . 1993 Oncogene 8: 1183–1193.

  • Rainwater R, Parks D, Anderson ME, Tegtmeyer P and Mann K. . 1995 Mol. Cell. Biol. 15: 3892–3903.

  • Raycroft L, Wu HY and Lozano G. . 1990 Science 249: 1049–1051.

  • Reich NC and Levine AJ. . 1984 Nature 308: 199–201.

  • Reich NC, Oren M and Levine AJ. . 1983 Mol. Cell. Biol. 3: 2143–2150.

  • Reznikov MV, Fidler R, Rubtsov PM, Skriabin KG, Chumakov PM, Prasolov VS and Baev AA. . 1989 Mol. Biol. (Mosk) 23: 1692–1699.

  • Rogel A, Popliker M, Webb CG and Oren M. . 1985 Mol. Cell. Biol. 5: 2851–2855.

  • Rotter V, Aloni-Grinstein R, Schwartz D, Elkind NB, Simons A, Wolkowicz R, Lavigne M, Beserman P, Kapon A and Goldfinger N. . 1994 Semin. Cancer Biol. 5: 229–236.

  • Rotter V, Witte ON, Coffman R and Baltimore D. . 1980 J. Virol. 36: 547–555.

  • Rovinsky B, Munroe D, Peacock J, Mawat M, Berstein A and Benchimol S. . 1987 Mol. Cell. Biol. 7: 853.

  • Ruppert JM and Stillman B. . 1993 Mol. Cell. Biol. 13: 3811–3820.

  • Sabbatini P, Lin JY, Levine AJ and White E. . 1995 Genes Dev. 9: 2184–2192.

  • Sakaguchi K, Herrera JE, Saito S, Miki T, Bustin M, Vassilev A, Anderson CW and Appella E. . 1998 Genes Dev. 12: 2831–2841.

  • Sakamuro D, Sabbatini P, White E and Prendergast GC. . 1997 Oncogene 15: 887–898.

  • Sarnow P, Ho YS, Williams J and Levine AJ. . 1982 Cell 28: 387–394.

  • Savitsky K, Bar-Shira A, Gilad S, Rotman G, Ziv Y, Vanagaite L, Tagle DA, Smith S, Uziel T and Sfez S. . 1995 Science 268: 1749–1753.

  • Scheffner M, Werness BA, Huibregtse JM, Levine AJ and Howley PM. . 1990 Cell 63: 1129–1136.

  • Schmale H and Bamberger C. . 1997 Oncogene 15: 1363–1367.

  • Scolnick DM, Chehab NH, Stavridi ES, Lien MC, Caruso L, Moran E, Berger SL and Halazonetis TD. . 1997 Cancer Res. 57: 3693–3696.

  • Selivanova G, Iotsova V, Okan I, Fritsche M, Strom M, Groner B, Grafstrom RC and Wiman KG. . 1997 Nat. Med. 3: 632–638.

  • Selivanova G, Ryabchenko L, Jansson E, Iotsova V and Wiman KG. . 1999 Mol. Cell. Biol. 19: 3395–3402.

  • Selvakumaran M, Lin HK, Miyashita T, Wang HG, Krajewski S, Reed JC, Hoffman B and Liebermann D. . 1994 Oncogene 9: 1791–1798.

  • Seto E, Usheva A, Zambetti GP, Momand J, Horikoshi N, Weinmann R, Levine AJ and Shenk T. . 1992 Proc. Natl. Acad. Sci. USA 89: 12028–12032.

  • Shaulsky G, Ben Ze'ev A and Rotter V. . 1990a Oncogene 5: 1707–1711.

  • Shaulsky G, Goldfinger N, Ben Ze'ev A and Rotter V. . 1990b Mol. Cell. Biol. 10: 6565–6577.

  • Shaw P, Bovey R, Tardy S, Sahli R, Sordat B and Costa J. . 1992 Proc. Natl. Acad. Sci. USA 89: 4495–4499.

  • Shaw P, Freeman J, Bovey R and Iggo R. . 1996 Oncogene 12: 921–930.

  • Sherr CJ. . 1998 Genes Dev. 12: 2984–2991.

  • Shohat O, Greenberg M, Reisman D, Oren M and Rotter V. . 1987 Oncogene 1: 277–283.

  • Siliciano JD, Canman CE, Taya Y, Sakaguchi K, Appella E and Kastan MB. . 1997 Genes Dev. 11: 3471–3481.

  • Slebos RJ, Resnick MA and Taylor JA. . 1998 Cancer Res. 58: 5333–5336.

  • Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM and Fornace Jr AJ. . 1994 Science 266: 1376–1380.

  • Soussi T, Caron de Fromentel C and May P. . 1990 Oncogene 5: 945–952.

  • Soussi T, Caron DF, Mechali M, May P and Kress M. . 1987 Oncogene 1: 71–78.

  • Soussi T and May P. . 1996 J. Mol. Biol. 260: 623–637.

  • Speir E, Modali R, Huang ES, Leon MB, Shawl F, Finkel T and Epstein SE. . 1994 Science 265: 391–394.

  • Steegenga WT, van der Eb AJ and Jochemsen AG. . 1996 J. Mol. Biol. 263: 103–113.

  • Stephen CW and Lane DP. . 1992 J. Mol. Biol. 225: 577–583.

  • Stewart N, Hicks GG, Paraskevas F and Mowat M. . 1995 Oncogene 10: 109–115.

  • Stommel JM, Marchenko ND, Jimenez GS, Moll U, Hope TJ and Wahl GM. . 1999 EMBO J. 18: 1660–1672.

  • Storey A, Thomas M, Kalita A, Harwood C, Gardiol D, Mantovani F, Breuer J, Leigh IM, Matlashewski G and Banks L. . 1998 Nature 393: 229–234.

  • Stott FJ, Bates S, James MC, McConnell BB, Starborg M, Brookes S, Palmero I, Ryan K, Vousden KH and Peters G. . 1998 EMBO J. 17: 5001–5014.

  • Strasser A, Harris AW, Corcoran LM and Cory S. . 1994 Nature 368: 457–460.

  • Sturzbecher HW, Chumakov P, Welch WJ and Jenkins JR. . 1987 Oncogene 1: 201–211.

  • Subler MA, Martin DW and Deb S. . 1992 J. Virol. 66: 4757–4762.

  • Szekely L, Selivanova G, Magnusson KP, Klein G and Wiman KG. . 1993 Proc. Natl. Acad. Sci. USA 90: 5455–5459.

  • Takenaka I, Morin F, Seizinger BR and Kley N. . 1995 J. Biochem. 270: 5405–5411.

  • Tao WK and Levine AJ. . 1999 Proc. Natl. Acad. Sci. USA 96: 6937–6941.

  • Thut CJ, Chen JL, Klemm R and Tjian R. . 1995 Science 267: 100–104.

  • Truant R, Xiao H, Ingles CJ and Greenblatt J. . 1993 J. Biol. Chem. 268: 2284–2287.

  • Unger T, Mietz JA, Scheffner M, Yee CL and Howley PM. . 1993 Mol. Cell. Biol. 13: 5186–5194.

  • Unger T, Nau MM, Segal S and Minna JD. . 1992 EMBO J. 11: 1383–1390.

  • Venot C, Maratrat M, Dureuil C, Conseiller E, Bracco L and Debussche L. . 1998 EMBO J. 17: 4668–4679.

  • Votja PJ and Barrett JC. . 1995 Bba-Rev. Cancer 1242: 29–41.

  • Wadgaonkar R and Collins T. . 1999 J. Biol. Chem. 274: 13760–13767.

  • Waga S, Hannon GJ, Beach D and Stillman B. . 1994 Nature 369: 574–578.

  • Waldman T, Kinzler KW and Vogelstein B. . 1995 Cancer Res. 55: 5187–5190.

  • Walker KK and Levine AJ. . 1996 Proc. Natl. Acad. Sci. USA 93: 15335–15340.

  • Wang XW, Forrester K, Yeh H, Feitelson MA, Gu JR and Harris CC. . 1994 Proc. Natl. Acad. Sci. USA 91: 2230–2234.

  • Wang XW, Vermeulen W, Coursen JD, Gibson M, Lupold SE, Forrester K, Xu G, Elmore L, Yeh H, Hoeijmakers JH and Harris CC. . 1996 Genes Dev. 10: 1219–1232.

  • Wang XW, Yeh H, Schaeffer L, Roy R, Moncollin V, Egly JM, Wang Z, Freidberg EC, Evans MK and Taffe BG. . 1995a Nat. Genet. 10: 188–195.

  • Wang XW, Yeh H, Schaeffer L, Roy R, Moncollin V, Egly JM, Wang Z, Friedberg EC, Evans MK, Taffe BG, Bohr VA, Weeda G, Hoeijmakers JHJ, Forrester K and Harris C. . 1995b Nat. Genet. 10: 188–195.

  • Wang Y and Prives C. . 1995 Nature 376: 88–91.

  • Wang Y, Reed M, Wang P, Stenger JE, Mayr G, Anderson ME, Schwedes JF and Tegtmeyer P. . 1993 Genes Dev. 7: 2575–2586.

  • White E. . 1996 Genes Dev. 10: 1–15.

  • Wu GS, Saftig P, Peters C and El-Deiry WS. . 1998 Oncogene 16: 2177–2183.

  • Wu X, Bayle JH, Olson D and Levine AJ. . 1993 Genes Dev. 7: 1126–1132.

  • Wynford-Thomas D. . 1999 J. Pathol. 187: 100–111.

  • Yang XJ, Ogryzko VV, Nishikawa J, Howard BH and Nakatini Y. . 1996 Nature 382: 319–324.

  • Yew PR and Berk AJ. . 1992 Nature 357: 82–85.

  • Yewdell JW, Gannon JV and Lane DP. . 1986 J. Virol. 59: 444–452.

  • Yonish-Rouach E, Bordé J, Gotteland M, Mishal Z, Viron A and May E. . 1994 Cell Death Differ. 1: 39–47.

  • Yonish-Rouach E, Deguin V, Zaitchouk T, Breugnot C, Mishal Z, Jenkins JR and May E. . 1995 Oncogene 11: 2197–2205.

  • Yonish-Rouach E, Grunwald D, Wilder S, Kimchi A, May E, Lawrence JJ, May P and Oren M. . 1993 Mol. Cell. Biol. 13: 1415–1423.

  • Yonish-Rouach E, Resnitzky D, Lotem J, Sachs L, Kimchi A and Oren M. . 1991 Nature 352: 345–347.

  • Zakut-Houri R, Bienz-Tadmor B, Givol D and Oren M. . 1985 EMBO J. 4: 1251–1255.

  • Zauberman A, Lupo A and Oren M. . 1995 Oncogene 10: 2361–2366.

  • Zhan QM, Bae I, Kastan MB and Fornace AJ. . 1994 Cancer Res. 54: 2755–2760.

  • Ziegler A, Jonason AS, Leffell DJ, Simon JA, Sharma HW, Kimmelman J, Remington L, Jacks T and Brash DE. . 1994 Nature 372: 773–776.

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May, P., May, E. Twenty years of p53 research: structural and functional aspects of the p53 protein. Oncogene 18, 7621–7636 (1999). https://doi.org/10.1038/sj.onc.1203285

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