Abstract
A number of studies have indicated that 8p22–p12 is likely to harbor schizophrenia susceptibility loci. In this region, the candidate gene of interest, neuregulin 1 (NRG1), may play a role in the pathogenesis of schizophrenia. Then in the present study, we performed the linkage disequilibrium to determine the association between three genetic variants (SNPs: rs3924999, rs2954041, SNP8NRG221533) on NRG1 gene and schizophrenia in 246 Chinese Han schizophrenic family trios using PCR-based restriction fragment length polymorphism method and denaturing high-performance liquid chromatography. The transmission disequilibrium test analysis for each variant showed a significant difference between two transmitted alleles even after Bonferroni correction (rs3924999, P=0.007752; rs2954041, P=0.0009309; SNP8NRG221533, P=0.012606). The global χ2 test for haplotype transmission also revealed a strong association (χ2=46.068, df=7, P<0.000001). Our results suggest that the NRG1 gene may play a role in conferring susceptibility to the disease.
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Acknowledgements
We express our gratitude to all patients and their family members, without whose cooperation, this work would not have been possible. We also thank Professor Lian Zhang, Professor Kaifeng Pang in Beijing Institute for Cancer Research in helping us to carry out dHPLC. This work has been supported by Grant H010210180112 from Beijing Biomedical R & D Innovation Program, Grant 30000059 from the National Natural Scientific Foundation of China, Grant 2000-A-A32 from Peking University Center for Human Disease Genomics, and Grant 2002BA711A07-06 from National Key Project.
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Yang, J., Si, T., Ruan, Y. et al. Association study of neuregulin 1 gene with schizophrenia. Mol Psychiatry 8, 706–709 (2003). https://doi.org/10.1038/sj.mp.4001377
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DOI: https://doi.org/10.1038/sj.mp.4001377
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