Abstract
Epidemiologicalstudies suggest that inherited factors influence susceptibility to inflammatory bowel disease (IBD), and some candidate loci have been described. In order to verifywhether the same loci are responsible for predisposition to IBD in our population, we carried out a linkage study in a series of 58 Italian families withCrohn's disease (CD) and ulcerative colitis (UC). HLA-DQ alleles, motilin gene, and 34 microsatellites flanking the previously described loci onchromosomes 3, 6, 7, 12 and 16 were analysed by non-parametric linkage analysis in 16 and 23 families with CD and UC, respectively, and in 19families where CD and UC coexisted. Non parametric analysis using GENEHUNTER yielded maximum NPL scores for marker D16S408 in all IBD familiescombined (2.71, P = 0.003), for marker D16S419 in CD (1.97, P = 0.026) and for marker D16S514 in UC families(2.44, P = 0.007). These markers map in the previously described IBD1 region. No significant linkage was found for markers ofchromosomes 3, 6, 7 and 12. The present study performed in a Southern European population provides additional support for the conclusion that theIBD1 locus has a clear role in the genetic susceptibility to IBD.
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Annese, V., Latiano, A., Bovio, P. et al. Genetic analysis in Italian families with inflammatory bowel disease supports linkage to the IBD1 locus – A GISC study. Eur J Hum Genet 7, 567–573 (1999). https://doi.org/10.1038/sj.ejhg.5200328
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DOI: https://doi.org/10.1038/sj.ejhg.5200328
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