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Microsatellite instability: The mutator that mutates the other mutator

Nature Medicine volume 2, pages 630–631 (1996)Cite this article

Microsatellite mutations are useful markers of both tumor clonality and genomic instability but the origin of the mutator mutations responsible is still not well understood (pages 676–681).

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References

  1. Streisinger, G. et al. Frameshift mutations and the genetic code. Cold Spring Harbor Symp. Quant. Biol. 31, 77–84 (1966).

    Article  CAS  PubMed  Google Scholar 

  2. Marra, G. & Boland, C.R. Hereditary nonpolyposis colorectal cancer (HNPCC): The syndrome, the genes, and historical perspectives. J. Natl. Cancer Institute 87, 1114–1125 (1995).

    Article  CAS  Google Scholar 

  3. Ionov, Y., Peinado, M.A., Malkhosyan, S., Shibata, D. & Perucho, M. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 363, 558–561 (1993).

    Article  CAS  PubMed  Google Scholar 

  4. Loeb, L.A. Mutator phenotype may be required for multistage carcinogenesis. Cancer Res. 51, 3075–3079 (1991).

    CAS  PubMed  Google Scholar 

  5. Shibata, D., Navidi, W., Salovaara, R., Li, Z-H. & Aaltonen, L.A. Somatic microsatellite mutations as molecular tumor clocks. Nature Med. 2, 676–681 (1996).

    Article  CAS  PubMed  Google Scholar 

  6. Shibata, D., Peinado, M.A., Ionov, Y., Malkhosyan, S. & Perucho, M. Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation. Nature Genet. 6, 273–281 (1994).

    Article  CAS  PubMed  Google Scholar 

  7. Markowitz, S.J. et al. Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability. Science 268, 1336–1338 (1995).

    Article  CAS  PubMed  Google Scholar 

  8. Knudson, A.G. Hereditary cancer, oncogenes and antioncogenes. Cancer Res. 45, 1437–1443 (1985).

    CAS  PubMed  Google Scholar 

  9. Perucho, M. et al. Defects in replication fidelity of simple repeated sequences reveal a new mutator mechanism for oncogenesis. Cold Spring Harbor Symps. Quant. Biol. 59, 339–348 (1994).

    Article  CAS  Google Scholar 

  10. Fearon, E.R. & Vogelstein, B. A genetic model for colorectal tumorigenesis. Cell 61, 759–767 (1990).

    Article  CAS  PubMed  Google Scholar 

  11. Casares, S., Ionov, Y., Ge, H.-Y., Stanbridge, E. & Perucho, M. The microsatellite mutator phenotype of colon cancer cells is often recessive, Oncogene 11, 2303–2310 (1995).

    CAS  PubMed  Google Scholar 

  12. Nowell, P. The clonal evolution of tumor cell populations. Science 194, 23–28 (1976).

    Article  CAS  PubMed  Google Scholar 

  13. de Wind, N., Dekker, M., Berns, A., Radman, M. & te Riele, H. Inactivation of the mouse MSH2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer. Cell 82, 321–330 (1995).

    Article  CAS  PubMed  Google Scholar 

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  1. The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California, 92037, USA

    Manuel Perucho

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  1. Manuel Perucho
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Perucho, M. Microsatellite instability: The mutator that mutates the other mutator. Nat Med 2, 630–631 (1996). https://doi.org/10.1038/nm0696-630

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