This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Spear, P. . in Viral Fusion Mechanisms. (ed. Bentz, J.) 201–232 (CRC, Boca Raton, 1993).
Roizman, B. & Sears, A.E. in Field's Virology (ed. Fields, B.N.) 1795–1841 (Raven, New York, 1990).
Fink, D., DeLuca, N.A., Coins, W. & Glorioso, J.C. Gene transfer to neurons using herpes simplex virus-based vectors. Ann. Rev. Neurosci. 19, 265–287 (1996a).
Stevens, J.G. Human herpesviruses: a consideration of the latent state. Mlcrobiol. Rev. 53, 318–332 (1989).
Batchelor, A.H. & O'Hare, P.O. Localization of cis-acting sequence requirements in the promoter of the latency-associated transcript of herpes simplex virus type-1 required for cell-type-specific activity. J. Virol. 66, 3573–3582 (1992).
Chen, X., Schmidt, M.C., Goins, W.F. & Glorioso, J.C. Two herpes simplex virus type-1 latency active promoters differ in their contribution to latency-associated transcript expression during lytic and latent infection. J. Virol. 69, 7899–7908 (1995).
Dobson, A.T. et al. Identification of the latency-associated transcript promoter by expression of rabbit β-globin mRNA in mouse sensory nerve ganglia latently infected with a recombinant herpes simplex virus. J. Virol. 63, 3844–3851 (1989).
Goins, W.F. et al. A novel latency-active promoter is contained within the herpes simplex virus type-1 UL flanking repeats. J. Virol. 68, 2239–2252 (1994).
Leiden, J., Frenkel, N. & Rapp, F. Identification of the herpes simplex virus DNA sequences present in six herpes simplex virus thymidine kinase-transformed mouse cell lines. J. Virol. 33, 272–285 (1980).
DeLuca, N.A., McCarthy, A.M. & Schaffer, P.A. Isolation and characterization of deletion mutants of herpes simplex virus type-1 in the gene encoding immediate-early regulatory protein ICP4. J. Virol. 56, 558–570 (1985a).
Marconi, P. et al. Replication-defective HSV vectors for gene transfer in vivo. Proc. Natl. Acad. Sci. USA 93, 11319–11320 (1996).
Wu, N., Watkins, S.C., Schaffer, P.A. & DeLuca, N.A. Prolonged gene expression and cell survival after infection by a herpes simplex virus mutant defective in the immediate-early genes encoding ICP4, ICP27, and ICP22. J. Virol. 70, 6358–6368 (1996b).
Ho, D.Y. & Mocarski, E.S. Herpes simplex virus latent RNA (LAT) is not required for latent infection in the mouse. Proc. Natl. Acad. Sci. USA 86, 7596–7600 (1989).
Oligino, T. et al. In vivo transgene activation from an HSV-based gene vector by GAL4:VP16. Gene Ther. 3, 892–899 (1996a).
Ramakrishnan, R., Levine, M. & Fink, D. PCR-based analysis of herpes simplex virus type-1 latency in the rat trigeminal ganglion established with a ribo-nucleotide reductase-deficient mutant. J. Virol. 68, 7083–7091 (1994a).
Ramakrishnan, R., Poliani, P., Levine, M., Glorioso, J.C. & Fink, D. Detection of herpes simplex virus type-1 latency-associated transcript expression in trigeminal ganglia by in situreverse transcriptase PCR. J. Virol. 70, 6519–6523 (1996a).
Celler, A. & Breakefield, X. A defective HSV-1 vector expresses Escherichia coliβ-galactosidase in cultured peripheral neurons. Science 241, 1667–1669 (1988).
Federoff, H., Geschwind, M., Geller, A. & Kessler, J. Expression of nerve growth factor in vivofrom a defective herpes simplex virus-1 vector prevents effects of ax-otomy on sympathetic ganglia. Proc. Natl. Acad. Sci. USA 89, 1636–1640 (1992).
Fraefel, C. et al. Helper virus-free transfer of herpes simplex virus type-1 plasmid vectors into neural cells. J. Virol. 70, 7190–7197 (1996).
Scares, M.K., Hwang, D.Y., Schmidt, M.C., Fink, D.J. & Glorioso, J.C. Cis-acting elements involved in transcriptional regulation of the herpes simplex virus type-1 latency-associated promoter 1 (LAP1) In vitro and in vivo. J. Virol. 70, 5384–5394 (1996).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Fink, D., Giorioso, J. Engineering herpes simplex virus vectors for gene transfer to neurons. Nat Med 3, 357–359 (1997). https://doi.org/10.1038/nm0397-357
Issue Date:
DOI: https://doi.org/10.1038/nm0397-357
This article is cited by
-
HIF1A overexpression using cell-penetrating DNA-binding protein induces angiogenesis in vitro and in vivo
Molecular and Cellular Biochemistry (2018)
-
Gene therapy for head and neck cancer
Cancer and Metastasis Reviews (2005)
-
Functional expression of ATM gene carried by HSV amplicon vector in vitro and in vivo
Gene Therapy (2004)
-
Gene therapy: Novel treatments for polyneuropathy and chronic pain
Current Neurology and Neuroscience Reports (2004)
-
Replication-defective herpes simplex virus vectors for neurotrophic factor gene transfer in vitro and in vivo
Gene Therapy (1999)
