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A contravention of Ohno's law in mice

Abstract

The chloride channel gene, CLCN4, has been previously mapped to the X chromosome in humans. We isolated a cDNA clone for mouse Clcn4 and used this to map the gene in an interspecific backcross. This revealed the surprising finding that the gene maps to the X chromosome in Mus spretus but to chromosome 7 in C57BL/6 mice. This is the first example of a gene that contravenes Ohno's law — it is a gene unique to the X chromosome in one eutherian species but autosomal in another. The consequence of this chromosomal rearrangement is that the gene is lost by mendelian segregation in a subset of the male progeny of a (C57BL/6 × Mus spretus) × Mus spretus backcross.

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Palmer, S., Perry, J. & Ashworth, A. A contravention of Ohno's law in mice. Nat Genet 10, 472–476 (1995). https://doi.org/10.1038/ng0895-472

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