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Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND

Nature Genetics volume 16, pages 154–160 (1997)Cite this article

An Erratum to this article was published on 01 August 1997

Abstract

dHAND and eHAND are related basic helix-loop-helix (bHLH) transcription factors that are expressed in mesodermal and neural crest-derived structures of the developing heart. In contrast to their homogeneous expression during avian cardiogenesis, during mouse heart development we show that dHAND and eHAND are expressed in a complementary fashion and are restricted to segments of the heart tube fated to form the right and left ventricles, respectively. dHAND and eHAND represent the earliest cardiac chamber-specific transcription factors yet identified. Targeted gene deletion of dHAND in mouse embryos resulted in embryonic lethality at embryonic day 10.5 from heart failure. Our description of the cardiac phenotype of dHAND mutant embryos is the first demonstration of a single gene controlling the formation of the mesodermally derived right ventricle and the neural crest-derived aortic arches and reveals a novel cardiogenic subprogramme for right ventricular development.

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Authors and Affiliations

  1. Departments of Pediatrics, Division of Cardiology & University of Texas Southwestern Medical Center, 5323 Harry Mines Boulevard, Dallas, Texas, 75235-9148, USA

    Deepak Srivastava & Tiffani Thomas

  2. Molecular Biology and Oncology, University of Texas Southwestern Medical Center, 5323 Harry Mines Boulevard, Dallas, Texas, 75235-9148, USA

    Deepak Srivastava, Qing Lin, Doris Brown & Eric N. Olson

  3. Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia, 30912, USA

    Margaret L. Kirby

Authors
  1. Deepak Srivastava
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  2. Tiffani Thomas
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  3. Qing Lin
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  4. Margaret L. Kirby
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  5. Doris Brown
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  6. Eric N. Olson
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Correspondence to Deepak Srivastava.

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Srivastava, D., Thomas, T., Lin, Q. et al. Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Nat Genet 16, 154–160 (1997). https://doi.org/10.1038/ng0697-154

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