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Germline RAD51C mutations confer susceptibility to ovarian cancer

Nature Genetics volume 44, pages 475–476 (2012)Cite this article

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To the Editor:

In 2010, Meindl and colleagues proposed that germline RAD51C mutations confer high risk for breast and ovarian cancer, comparable to BRCA1 and BRCA2 mutations1,2. However, multiple follow-up studies have provided no supportive evidence that RAD51C mutations predispose to breast cancer3,4,5,6,7,8,9,10,11,12.

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References

  1. Levy-Lahad, E. Nat. Genet. 42, 368–369 (2010).

    Article  CAS  PubMed  Google Scholar 

  2. Meindl, A. et al. Nat. Genet. 42, 410–414 (2010).

    Article  CAS  PubMed  Google Scholar 

  3. Zheng, Y. et al. Breast Cancer Res. Treat. 124, 857–861 (2010).

    Article  CAS  PubMed  Google Scholar 

  4. Akbari, M.R. et al. Breast Cancer Res. 12, 404 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Silvestri, V. et al. Breast Cancer Res. 13, 404 (2011).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Wong, M.W. et al. Breast Cancer Res. Treat. 127, 853–859 (2011).

    Article  CAS  PubMed  Google Scholar 

  7. Romero, A. et al. Breast Cancer Res. Treat. 129, 939–946 (2011).

    Article  CAS  PubMed  Google Scholar 

  8. Pang, Z. et al. Breast Cancer Res. Treat. 129, 1019–1020 (2011).

    Article  PubMed  Google Scholar 

  9. Pelttari, L.M. et al. Hum. Mol. Genet. 20, 3278–3288 (2011).

    Article  CAS  PubMed  Google Scholar 

  10. Vuorela, M. et al. Breast Cancer Res. Treat. 130, 1003–1010 (2011).

    Article  CAS  PubMed  Google Scholar 

  11. Clague, J. et al. PLoS ONE 6, e25632 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Thompson, E.R. et al. Hum. Mutat. 33, 95–99 (2012).

    Article  CAS  PubMed  Google Scholar 

  13. Loveday, C. et al. Nat. Genet. 43, 879–882 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Ahmed, M. & Rahman, N. Oncogene 25, 5906–5911 (2006).

    Article  CAS  PubMed  Google Scholar 

  15. Seal, S. et al. Nat. Genet. 38, 1239–1241 (2006).

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

We thank all the subjects and families that participated in the research and the many individuals that assisted in their recruitment. We are grateful to R. Houlston for coordination of the collection of the unselected ovarian series. We acknowledge the use of DNA from the British 1958 Birth Cohort collection. We acknowledge NHS funding to the National Institute for Health Research (NIHR) Biomedical Research Centre. This work was funded by Cancer Research UK (C8620/A8372 and C8620/A8857) and the Institute of Cancer Research (UK). C.T. is a Medical Research Council (MRC)-funded Clinical Research Fellow. A.C.A. is a Cancer Research UK Senior Cancer Research Fellow (C12292/A11174). Informed consent was obtained from participants, and the research was approved by the London Multicentre Research Ethics Committee (MREC/01/2/18).

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Author notes

  1. Chey Loveday and Clare Turnbull: These authors contributed equally to this work.

Authors and Affiliations

  1. Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, UK

    Chey Loveday, Clare Turnbull, Elise Ruark, Rosa Maria Munoz Xicola, Emma Ramsay, Deborah Hughes, Margaret Warren-Perry, Katie Snape, Anthony Renwick, Sheila Seal & Nazneen Rahman

  2. Faculty of Medicine, University of Southampton, Southampton University Hospital National Health Service (NHS) Trust, Southampton, UK

    Diana Eccles

  3. University Department of Medical Genetics & Regional Genetics Service, St Mary's Hospital, Manchester, UK

    D Gareth Evans

  4. Department of Gynaecologic Oncology, Royal Marsden Hospital NHS Foundation Trust, London, UK

    Martin Gore

  5. Department of Public Health and Primary Care, Center for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK

    Antonis C Antoniou

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  1. Chey Loveday
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  15. Nazneen Rahman
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Breast Cancer Susceptibility Collaboration (BCSC) (UK)

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Correspondence to Nazneen Rahman.

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The authors declare no competing financial interests.

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Supplementary Methods, Supplementary Figure 1, Supplementary Tables 1–3 and Supplementary Note (PDF 231 kb)

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Loveday, C., Turnbull, C., Ruark, E. et al. Germline RAD51C mutations confer susceptibility to ovarian cancer. Nat Genet 44, 475–476 (2012). https://doi.org/10.1038/ng.2224

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