Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Feature
  • Published:

Genetic testing: The problems and the promise

Nature Biotechnology volume 15, pages 422–426 (1997)Cite this article

Though several technical hurdles remain, effective and reliable genetic tests for multigene diseases should be available within the next five years.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Chang, J.C. and Kan, Y.W. 1982. N. Engl. J. Med. 307: 30–32.

    Article  CAS  Google Scholar 

  2. Friend, S.H. et al. 1986. Nature 323: 643–646.

    Article  CAS  Google Scholar 

  3. Toguchida, J. et al. 1988. Cancer Res. 48: 3939–3943.

    CAS  PubMed  Google Scholar 

  4. Blanquet, V. et al. 1995. Hum. Mol. Genet. 4: 383–388.

    Article  CAS  Google Scholar 

  5. Liu, Z., Song, Y., Bia, B.., and Cowell, J.K. 1995. Genes Chrom. Cancer 14: 277–284.

    Article  Google Scholar 

  6. Lohmann, D.R., Brandt, B., Höpping, W., Passarge, E., and Horsthemke, B. 1996. Am. J. Hum. Genet. 58: 940–949.

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Lohmann, D.R., Brandt, B., Höpping, W., Passarge, E., and Horsthemke, B. 1994. Hum. Genet. 94: 349–354.

    Article  CAS  Google Scholar 

  8. Lohmann, D.R., Brandt, B., Hopping, W., Passarge, E., and Horsthemke, B. 1994. Hum. Mol. Genet. 3: 2187–2193.

    Article  CAS  Google Scholar 

  9. Noorani, H.Z., Khan, H.N., Gallie, B.L., and Detsky, A.S. 1996. Am. J. Hum. Genet. 59: 301–307.

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Brown, M.L. and Kessler, L.G. 1996. Int. J. Cancer 69: 55–57.

    Article  CAS  Google Scholar 

  11. Miki, Y. et al. 1994. Science 266: 66–71.

    Article  CAS  Google Scholar 

  12. Lerman, C. et al. 1996. J. Am. Med. Assoc. 275: 85–1892.

    Article  Google Scholar 

  13. Abbott, A. 1996. Nature 379: 390.

    Article  CAS  Google Scholar 

  14. Collins, F.S. 1995. N. Engl. J. Med. 334: 186–188.

    Article  Google Scholar 

  15. Wooster, R. et al. 1995: Nature 378: 789–792

    Article  CAS  Google Scholar 

  16. Tavtigian, S.V. et al. 1996. Nature Genet. 12: 333–337.

    Article  CAS  Google Scholar 

  17. Tonin, P. et al. 1996. Nature Med. 2: 117–1183.

    Article  Google Scholar 

  18. Sidransky, D. et al. 1992. Cancer Res. 52: 2984–2986.

    CAS  PubMed  Google Scholar 

  19. Savitsky, K. et al. 1995. Hum. Mol. Genet. 4: 2025–2032.

    Article  CAS  Google Scholar 

  20. Liaw, D. et al. 1997. Nature Genet. in press.

  21. Fishel, R. and Kolodner, R.D. 1995. Curr. Opin. Genet. Dev. 5: 382–395.

    Article  CAS  Google Scholar 

  22. Stern, H.J., Carlos, R.D., and Schuzbank, T.E. 1995. Clin. Biochem. 28: 470–473.

    Article  CAS  Google Scholar 

  23. Sanger, F., Nicklen, S., and Coulson, A.R. 1977. Proc. Natl. Acad. Sci. USA 74: 5463–5467.

    Article  CAS  Google Scholar 

  24. Chetverin, A.B. and Russell Kramer, F. 1994. Bio/Technology 12: 1093–1099.

    Article  CAS  Google Scholar 

  25. Beattie, W.G. et al. 1995. Mol. Biotechnol. 4: 213–225.

    Article  CAS  Google Scholar 

  26. Kozal, M.J. et al. 1996. Nature Med. 2: 753–759.

    Article  CAS  Google Scholar 

  27. Chee, M. et al. 1996. Science 274: 610–614.

    Article  CAS  Google Scholar 

  28. Hacia, J.G., Brody, L.C., Chee, M.S., Fodor, S.P.A., and Collins, F.S. 1996. Nature Genet. 14: 441–447.

    Article  CAS  Google Scholar 

  29. Liu, B. et al. 1994. Cancer Res. 54: 4590–4594.

    CAS  Google Scholar 

  30. Liu, B. et al. 1996. Nature Med 2: 169–173.

    Article  CAS  Google Scholar 

  31. FitzGerald, M.G. et al. 1996. N. Engl. J. Med. 334: 143–149.

    Article  CAS  Google Scholar 

  32. Xia, L. et al. 1996. Cancer Res. 56: 2289–2292.

    CAS  PubMed  Google Scholar 

  33. Phelan, C.M. et al. 1996. Nature Genet. 13: 120–122.

    Article  CAS  Google Scholar 

  34. Couch, F.J. et al. 1996. Nature Genet. 13: 123–128.

    Article  CAS  Google Scholar 

  35. Orita, N., Iwahana, H., Kanazawa, H., Hayashi, K., and Sekiya, T. 1989. Proc. Natl. Acad. Sci. USA 86: 2766–2770.

    Article  CAS  Google Scholar 

  36. Liu, Q. and Sommer, S.S. 1995. BioTechniques 18: 470–477.

    CAS  Google Scholar 

  37. Sarkar, G., Yoon, H.-S., and Sommer, S.S. 1992. Genomics 13: 441–443.

    Article  CAS  Google Scholar 

  38. Mashal, R.D., Koontz, J., and Sklar, J. 1995. Nature Genet. 9: 177–183.

    Article  CAS  Google Scholar 

  39. Youil, R., Keker, B.W., and Cotton, R.G.H. 1995. Proc. Natl. Acad. Sci. USA 92: 87–91.

    Article  CAS  Google Scholar 

  40. Fischer, S.G. and Lerman, L.S. 1979.Cell 16: 191–200.

    Article  CAS  Google Scholar 

  41. Lerman, LS. and Silverstein, K. 1987. Methods Enzymol. 155: 482–501.

    Article  CAS  Google Scholar 

  42. Guldberg, P., Henriksen, K.F., and Guttler, F. 1993. Genomics 17: 141–146.

    Article  CAS  Google Scholar 

  43. van Orsouw, N. et al. 1996. Hum. Mol. Genet. 5: 755–761.

    Article  CAS  Google Scholar 

  44. Wu, Y., et al 1996. Hum. Mutat. 8: 160–167.

    Article  CAS  Google Scholar 

  45. Nystrom-Lahti, M. et al. 1996. Hum. Mol. Genet 5: 763–769.

    Article  CAS  Google Scholar 

  46. Wu, Y. et al. 1997. Genes, Chrom, Cancer, in press.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. director of the translational research laboratory in the division of cancer epidemiology and control, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA, 02115-6084

    Charis Eng

  2. Director of the molecular genetics section, Gerontology Division, Beth Israel Hospital, 77 Avenue Louis Pasteur, Boston, MA, 02115

    Jan Vijg

Authors
  1. Charis Eng
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jan Vijg
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Eng, C., Vijg, J. Genetic testing: The problems and the promise. Nat Biotechnol 15, 422–426 (1997). https://doi.org/10.1038/nbt0597-422

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt0597-422

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing