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Connecting Fanconi anemia to BRCA1

The genetic basis of Fanconi anemia (FA) is mysterious and complex, as none of the five genes previously associated with the disorder have homology to genes encoding proteins of known function. The product of a sixth, newly-cloned FA-associated gene has been linked to BRCA1, and may finally offer some insight into the mechanism by which FA increases cancer susceptibility.

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Figure 1: Current view on the Fanconi anemia (FA) pathway of genome stabilization.

Stephen Horwitz

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Joenje, H., Arwert, F. Connecting Fanconi anemia to BRCA1. Nat Med 7, 406–407 (2001). https://doi.org/10.1038/86458

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