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Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling

Nature volume 386, pages 735–738 (1997)Cite this article

Abstract

The transcription factor CBP, originally identified as a coactivator for CREB1,2, enhances transcription mediated by many other transcription factors3–7. Mutations in the human CBP gene are associated with Rubinstein–Taybi syndrome, a haploinsufficiency disorder characterized by abnormal pattern formation8, but the mechanism by which decreased CBP levels affect pattern formation is unclear. The hedgehog (hh) signalling pathway is an important determinant of pattern formation, cubitus interruptus (ci), a component in hh signalling, encodes a transcription factor homologous to the Gli family of proteins9 and is required for induction of the hh-dependent expression of patched (ptc), decapentaplegic (dpp) and wingless (wg)10. Haploinsufficiency for the ci-related transcription factor Gli3 causes phenotypic changes in mice (known as 'extra-toes)11 and humans (Greig's cephalopolysyndactyly syndrome)12 that have similarities to Rubinstein-Taybi syndrome. Here we show that Drosophila CBP (dCBP) functions as a coactivator of Ci, suggesting that the dCBP-Ci interaction may shed light on the contribution of CBP to pattern formation in mammals.

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Author notes

  1. Hiroshi Akimaru and Yang Chen: These authors contributed equally to this work.

Authors and Affiliations

  1. Laboratory of Molecular Genetics, Tsukuba Life Science Center, The Institute of Physical and Chemical Research (RIKEN), Tsukuba, Ibaraki, 305, Japan

    Hiroshi Akimaru, Ping Dai, De-Xing Hou, Maki Nonaka & Shunsuke Ishii

  2. Vollum Institute, Oregon Health Sciences Unviersity, Portland, Oregon, 97201, USA

    Yang Chen & Richard H. Goodman

  3. Department of Molecular and Medical Genetics, Oregon Health Sciences Unviersity, Portland, Oregon, 97201, USA

    Sarah M. Smolik & Steve Armstrong

Authors
  1. Hiroshi Akimaru
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  3. Ping Dai
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  4. De-Xing Hou
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  9. Shunsuke Ishii
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Akimaru, H., Chen, Y., Dai, P. et al. Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling. Nature 386, 735–738 (1997). https://doi.org/10.1038/386735a0

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