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β2-Microglobulin deficient mice lack CD48+ cytolytic T cells

Abstract

Mice homozygous for a β2-microglobulin gene disruption do not express any detectable β2-ITL protein. They express little if any functional major histocompatibility complex (MHC) class I antigen on the cell surface yet are fertile and apparently healthy. They show a normal distribution of γδ, CD4+8+ and CD4+8 cells, but have no mature CD48+ cells and are defective in CD48+ cell-mediated cytotoxicity. Our results strongly support earlier evidence that MHC class I molecules are crucial for positive selection of T cell antigen receptor αβ+ CD48+ T cells in the thymus and call into question the non-immune functions that have been ascribed to MHC class I molecules.

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Zijlstra, M., Bix, M., Simister, N. et al. β2-Microglobulin deficient mice lack CD48+ cytolytic T cells. Nature 344, 742–746 (1990). https://doi.org/10.1038/344742a0

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