Abstract
Mice homozygous for a β2-microglobulin gene disruption do not express any detectable β2-ITL protein. They express little if any functional major histocompatibility complex (MHC) class I antigen on the cell surface yet are fertile and apparently healthy. They show a normal distribution of γδ, CD4+8+ and CD4+8− cells, but have no mature CD4−8+ cells and are defective in CD4−8+ cell-mediated cytotoxicity. Our results strongly support earlier evidence that MHC class I molecules are crucial for positive selection of T cell antigen receptor αβ+ CD4−8+ T cells in the thymus and call into question the non-immune functions that have been ascribed to MHC class I molecules.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Sawicki, J. A., Magnuson, T. & Epstein, C. J. Nature 294, 450–451 (1981).
Klein, J. et al. Nature 291, 455–460 (1981).
Zinkernagel, R. M. & Doherty, P. C. Adv. Immun. 27, 51–117 (1979).
Bevan, M. J. & Fink, P. Immunol. rev. 42, 3–19 (1978).
Von Boehmer, H. A. Rev. Immun. 6, 309–326 (1988).
Marrack, P. & Kappler, J. Immun. Today 9, 308–315 (1988).
Curtis, A. S. G. & Rooney, P. Nature 281, 222–223 (1979).
Bartlett, P. F. & Edidin, M. J. Cell Biol. 77, 377–388 (1978).
Verland, S. et al. J. Immun. 143, 945–951 (1989).
Kittur, D. et al. Proc. natn. Acad. Sci. U.S.A. 84, 1351–1355 (1987).
Hansen, T. et al. Proc. natn. Acad. Sci. U.S.A. 86, 3123–3126 (1989).
Schreiber, A. B., Schlessinger, J. & Edidin, M. J. cell Biol. 98, 725–731 (1984).
Solano, A. R. et al. Proc. natn. Acad. Sci. U.S.A. 85, 5087–5091 (1988).
Singh, P. B., Brown, R. E. & Roser, B. Nature 327, 161–164 (1987).
Yamazaki, K. et al. Science 240, 1331–1332 (1988).
Simister, N. E. & Mostov, K. E. Nature 337, 184–187 (1989).
Brinckerhoff, C. E. et al. Science 243, 655–657 (1989).
Dargemont, C. et al. Science 246, 803–806 (1989).
Zijlstra, M. et al. Nature 342, 435–438 (1989).
Koller, B. H. & Smithies, O. Proc. natn. Acad. Sci. U.S.A. 86, 8932–8935 (1989).
Parnes, J. R., Robinson, R. R. & Seidman, J. G. Nature 302, 449–452 (1983).
Hansen, T. H., Myers, N. B. & Lee, D. R. J. Immun. 140, 3522–3527 (1988).
Allen, H. et al. Proc. natn. Acad. Sci. U.S.A. 83, 7447–7451 (1987).
Williams, D. B. et al. J. Immun. 142, 2796–2806 (1989).
Potter, T. A., Boyer, C., Schmitt-Verhulst, A. M., Golstein, P. & Rajan, T. V. J. exp. Med. 160, 317–322 (1984).
Simister, N. E. & Rees, A. R. Eur. J. Immun. 15, 733–738 (1985).
Nikolic-Zugic, J., Moore, M. W. & Bevan, M. J. Eur. J. Immun. 19, 649–653 (1989).
Guidos, C. J., Weissman, I. L. & Adkins, B. A. Proc. natn. Acad. Sci. U.S.A. 86, 7542–7546 (1989).
Matis, L. A., Cron, R. & Bluestone, J. A. Nature 330, 263–264 (1987).
Bonneville, M. et al. Proc. natn Acad. Sci. U.S.A. 86, 5928–5932 (1989).
Vidovic, D. et al. Nature 340, 646–650 (1989).
Raulet, D. H. A. Rev. Immun. 7, 175–207 (1989).
Bernabeu, C. et al. Nature 308, 642–645 (1985).
Kisielow, P. et al. Nature 333, 742–747 (1988).
Von Boehmer, H., Teh, H. S. & Kisielow, P. Immun. Today 10, 57–61 (1989).
Sha, W. C. et al. Nature 335, 271–274 (1988).
Marusîc-Galesic, S. et al. Nature 333, 180–183 (1988).
Zuniga-Pflucker, J. C., Longo, D. L. & Kruisbeek, A. M. Nature 338, 76–78 (1989).
Stallcup, K. C., Springer, T. A. & Mescher, M. F. J. Immun. 127, 923–930 (1981).
Hämmerling, G., Rusch, E., Tada, N. Kimura, S. & Hämmerling, U. Proc. natn. Acad. Sci. U.S.A. 79, 4737–4741 (1982).
Lemke, H. Hämerling, G. J. & Hämmerling, U. Immun. Rev. 47, 175–206 (1979).
Kohler, G., Fischer-Lindahl, K. & Heusser, C. in The Immune System (eds Steinberg, S. G. & Lefkovits, L.) 2, 202 (Karger, Basel, 1981).
Ozato, K. & Sachs, D. H. J. Immun. 126, 317–321 (1981).
Sherman, L. A. & Randolph, C. P. Immunogenetics 12, 183–186 (1981).
Lynes, M. A., Tonkonogy, S. & Flaherty, L. J. Immun. 129, 928–934 (1982).
Sharrow, S. O., Arn, J. S., Stroynowski, I., Hood, L. & Sachs, D. H. J. Immun. 142, 3495–3502 (1989).
Daniel, D. et al. EMB0 J. 2, 1061–1065 (1983).
Thomas, K. R. & Capecchi, M. R. Cell 51, 503–512 (1987).
LaLanne, F. et al. Nucleic Acids Res. 11, 1567–1577 (1983).
Laemmli, U. K. Nature 227, 680–685 (1970).
Holsti, M. A. & Raulet, D. H. J. Immun 143, 2514–2519 (1989).
Kubo, R. T., Born, W. Kappler, J. W., Marrack, P. & Pigeon, M. J. Immun. 142, 2736–2742 (1989).
Havran, W. L. et al. Proc. natn. Acad. Sci. U.S.A. 86, 4185–4189 (1989).
Raulet, D. H. et al. J. Immun 125, 1136–1143 (1980).
Ohlen, C. et al. Science 246, 666–668 (1989).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Zijlstra, M., Bix, M., Simister, N. et al. β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells. Nature 344, 742–746 (1990). https://doi.org/10.1038/344742a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/344742a0
This article is cited by
-
Antigen recognition detains CD8+ T cells at the blood-brain barrier and contributes to its breakdown
Nature Communications (2023)
-
Mesenchymal stromal cells equipped by IFNα empower T cells with potent anti-tumor immunity
Oncogene (2022)
-
New fluid biomarkers tracking non-amyloid-β and non-tau pathology in Alzheimer’s disease
Experimental & Molecular Medicine (2020)
-
Epidemiological survey and risk factor analysis of dialysis-related amyloidosis including destructive spondyloarthropathy, dialysis amyloid arthropathy, and carpal tunnel syndrome
Journal of Bone and Mineral Metabolism (2020)
-
Serum beta2-microglobulin levels are highly associated with the risk of acute ischemic stroke
Scientific Reports (2019)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.