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The Apolipoprotein CI A Allele As a Risk Factor for Alzheimer's Disease

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Abstract

The E4 allele for the apolipoprotein E gene has been shown to be a significant risk factor for Alzheimer's disease. The gene is located in a conserved gene cluster on chromosome 19q12-13.2. Downstream from APOE is the gene for apolipoprotein CI. We had previously shown that the presence of a restriction site in the 5′end of APOCI (the A allele) was present at increased frequency in Alzheimer's patients and could also be considered as a risk factor for the disease. We have extended these studies and find that both familial and sporadic cases of Alzheimer's disease have a higher frequency of the APOCI A allele than control spouses. In addition, male patients with the APOCI A allele and/or the APOE4 allele tend to have an earlier age of onset of the disease than female patients.

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Authors and Affiliations

  1. Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, Texas

    S.E. Poduslo, M. Neal, K. Herring & J. Shelly

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  1. S.E. Poduslo
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  2. M. Neal
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  3. K. Herring
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  4. J. Shelly
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Poduslo, S., Neal, M., Herring, K. et al. The Apolipoprotein CI A Allele As a Risk Factor for Alzheimer's Disease. Neurochem Res 23, 361–367 (1998). https://doi.org/10.1023/A:1022409617539

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