Abstract
Background: In an earlier study it has been found that allergic symptoms and sensitization in adults were more frequent in Hamburg (northern part of West Germany) compared to Erfurt (East Germany). The purpose of this study was to replicate these findings using data from Augsburg, a city from the southern part of West Germany. Furthermore the study population in this analysis was extended to higher age groups. Methods: The prevalence of respiratory symptoms, assessed by a self-administered questionnaire, was compared in a random sample of adults, 25–64years of age, living in Augsburg (n = 1572) and Erfurt (n = 1648). From a subset (n = 754, resp. 1144) specific IgE to common aeroallergens were measured and atopic sensitization was defined as the presence of at least one positive specific IgE (CAP > 0). Results: The prevalence of allergic rhinitis, wheezing, asthma and atopic sensitization was higher in Augsburg than in Erfurt (OR: 2.0; 1.3; 2.1; 1.7; all p < 0.01). For these differences no specific explanation could be found, i.e. the percentage of sensitized persons was equally increased in Augsburg for asthmatics, patients with hay fever or asymptomatic subjects. Furthermore, sensitization was equally increased for all common allergens. The differences were largest for the youngest age group, but also existed for higher ages. Conclusions: The increased prevalence of allergies observed in Hamburg, a northern city of West Germany, is also found in Augsburg, a southern city of West Germany, both compared to Erfurt in East Germany. This supports the finding that unspecific causes related to western lifestyle play an important role. Further research is needed to identify the causal influences.
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References
Burney P, et al. for ECRHS. The European Community Respiratory Health Survey. European study protocols. Eur Respir J 1994; 7: 954-960.
Burney P, et al. for ECRHS. Variations in the prevalence of respiratory symptoms, selfreported asthma attacks, and the use of asthma medication in the European Community Respiratory Health Survey (ECRHS). Eur Respir J 1996; 9: 687-695.
Burney P, et al. for ECRHS. The distribution of total and specific serum IgE in the European Community Respiratory Health Survey. J Allergy Clin Immunol 1997; 99: 314-322.
Nowak D, Heinrich J, Jörres R, et al. Prevalence of respiratory symptoms, bronchial hyperresponsiveness and atopy among adults: West and East Germany. Eur Respir J 1996; 9: 2541-2552.
Beasley R, Keil U, von Mutius E, Pearce N for ISAAC. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. Lancet 1998; 351: 1225-1232.
WHO MONICA Project Principal Investigators (prep. by Tunstall-Pedoe, H). The World Health Organization MONICA Project. A major international collaboration. J Clin Epidemiol 1988; 41: 104-114.
Filipiak B, Schneider A, Döring A, Sticber J, Keil U. Trends in cardiovascular risk factors from survey 1984/85 to 1994/95. Data-Book. MONICA Project Augsburg. GSF-Bericht 27/97. Neuherberg: GSF, 1997.
Heinrich J, Beck E, Wassmer G, Wichmann HE. Die Häufigkeit von Asthma, Atemwegssymptomen und von allergischer Rhinitis bei Erwachsenen in einer ostdeutschen Großstadt. Allergologie 1995; 11: 539-646.
Fleiss J. Methods in Epidemiology. New York: Wily, 1980.
Heinrich J, Richter K, Magnussen H, Wichmann HE. Is the prevalence of atopic diseases in East and West Germany already converging? Eur J Epidemiol 1998; 14: 239-245.
de Marco R, Verlato G, Zanolin E, Bugiani M, Drane JW. Nonresponse bias in EC Respiratory Health Survey in Italy. Eur Respir J 1994; 7: 2139-2145.
Trepka MJ, Heinrich J, Wichmann HE. The epidemiology of atopic diseases in Germany: An East-West comparison. Rev Environ Health 1996; 11: 119-131.
von Mutius E, Martinez FD, Fritsch C, Nicolai T, Röll G, Thiemann HH. Prevalence of asthma and atopy in two areas of West and East Germany. Am J Respir Crit Care Med 1994; 149: 358-364.
Krämer U, Behrendt H, Ring J. Air pollution as a risk factor for allergy — The east-west German experience. In: Ring J (ed.), New Trends in Allergy IV, Berlin: Springer, 1996: 25-35.
Nicolai T, Bellach B, V Mutius E, Thefeld W, Hoffmeister H. Increased prevalence of sensitization against aeroallergens in adults in West and East Germany. Clin Exp Allergy 1997; 27: 886-892.
Braback L, Breborowicz A, Dreborg S, Knutsson A, Pieklik H, Björksten B. Atopic sensitization and respiratory symptoms among Polish and Swedish school children. Clin Exp Allergy 1994; 24: 826-835.
Jögi R, Janson C, Björnsson E, Boman G, Björksten B. Atopy and allergic disorders among adults in Tartu, Estonia compared with Uppsala, Sweden. Clin Exp Allergy 1998; 28: 1072-1080.
Wichmann HE. Possible explanation for the different trends of asthma and allergy in East and West Germany. Clin Exp Allergy 1996; 26: 621-623.
Nowak D, Wichmann HE, Magnussen H. Asthma and atopy in western and eastern communities current status and open questions. Clin Exp Allergy 1998; 28: 1043-1046.
Krämer U, Heinrich J, Wjst M, Wichmann HE. Age of entry to day nursery and allergy in later childhood. Lancet 1999; 353: 450-454.
Weiland SK, von Mutius E, Hüsing A, Asher MI. Intake of trans fatty acids and prevalence of childhood asthma and allergies in Europe. ISAAC Steering Committee. Research Letter. Lancet 1999; 353: 2040-2041.
Heinrich J, Wjst M. Increase of allergy in East Germany, Letter. Lancet 1998; 351: 1813.
von Mutius E, Weiland SK, Fritzsch C, Duhme H, Keil U. Increasing prevalence of hay fever and atopy among children in Leipzig, East Germany. Lancet 1998; 351: 862-866.
Weiland SK, von Mutius E, Hirsch T, et al. Prevalence of respiratory and atopic disorders among children in the East and West of Germany five years after unification. Eur Respir J 1999; 14: 862-870.
Wüthrich B, Schindler C, Medici TC, Zellweger JP, Leuenberger P and the SAPALDIA-team. IgE levels, atopy markers and hay fever in relation to age, sex and smoking status in a normal adult Swiss population. Int Arch Allergy Immunol 1996; 111: 396-402.
Neukirch F, Pin I, et al. Prevalence of asthma and asthma-like symptoms in three French cities. Respir Med 1995; 89: 685-692.
Droste JHJ, Kerkhoff M, de Monchy JGR, Schouten JP, Rijcken B and the Dutch ECRHS Group. Association of skin test reactivity, specific IgE, total IgE, and eosinophils with nasal symptoms in a community-based population study. J Allergy Clin Immunol 1996; 97: 922-932.
Kerkhof M, Droste JH, de Monchy JG, Schouten JP, Rijcken B. Distribution of total IgE and specific IgE to common aeroallergens by sex and age, and their relationship to each other in a random sample of the Dutch general population aged 20–70 years. Dutch ECRHS Group, European Community Respiratory Health Study. Allergy 1996; 51: 770-776.
Omenaas E, Bakke P, Elsayed S, Hanoa R, Gulsvik A. Total and specific IgE levels in adults relationship to sex, age and environmental factors. Clin Exp Allergy 1994; 44: 530-539.
Wieringa MH, Weyler JJ, Van Bastelaer FJ, Nelen VJ, Van Sprundel MP, Vermeire PA. Higher asthma occurrence in a urban than a suburban area: Role of house dust mite skin allergy. Eur Respir J 1997; 10: 1460-1466.
Jögi R, Janson C, Björnsson E, Boman G, Björksten B. The prevalence of asthmatic respiratory symptoms among adults in Estonian and Swedish university cities. Allergy 1996; 51: 331-336.
Gergen PJ, Turkeltaub PC, Kovar MG. The prevalence of allergic skin test reactivity to eight common aeroallergens in the U.S. population: Results from the second National Health and Nutrition examination Survey. J Allergy Clin Immunol 1987; 80: 669-679.
Gergen PJ, Turkeltaub PC. The association of allergen skin test reactivity and respiratory disease among whites in the US population. Data from the second National Health and Nutrition examination Survey 1976 to 1980. Arch Intern Med 1991; 151: 487-492.
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Filipiak, B., Heinrich, J., Nowak, D. et al. The distribution in specific IgE and the prevalence of allergic symptoms in25–64-years old inhabitants of an eastern and a western German city – Results from Augsburg and Erfurt. Eur J Epidemiol 17, 77–84 (2001). https://doi.org/10.1023/A:1010979522339
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DOI: https://doi.org/10.1023/A:1010979522339