Elsevier

Microbes and Infection

Volume 15, Issues 8–9, July–August 2013, Pages 630-639
Microbes and Infection

Review
NLRP7 and related inflammasome activating pattern recognition receptors and their function in host defense and disease

https://doi.org/10.1016/j.micinf.2013.04.001Get rights and content
Under an Elsevier user license
open archive

Abstract

Host defense requires the maturation and release of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18 and the induction of pyroptotic cell death, which depends on the activation of inflammatory Caspases within inflammasomes by innate immune cells. Several cytosolic pattern recognition receptors (PRRs) have been implicated in this process in response to infectious and sterile agonists. Here we summarize the current knowledge on inflammasome-organizing PRRs, emphasizing the recently described NLRP7, and their implications in human disease.

Keywords

Inflammasome
Pattern recognition receptor
Nod-like receptor
AIM2-like receptor
Inflammation
Hydatidiform mole

Cited by (0)