Trends in Molecular Medicine
Mouse models for the study of Crohn's disease
Section snippets
Traditional murine models of CD
Several animal models of intestinal inflammation have been developed using chemical induction, immune cell transfer, or genetic manipulations [3]. Each has unique advantages for characterizing specific biological mechanisms of gut inflammation.
Mouse models of CD ileitis
Two new murine models of Crohn's-like ileitis have been described (Table 1) 19, 20. These models provide exciting systems for investigating the underlying causes of CD and developing novel therapies.
Concluding remarks
The development of several mouse models of intestinal inflammation in recent years has allowed significant progress in our understanding of the mechanisms involved in chronic intestinal inflammation. Each animal model described under the four different categories of chemically induced, immunologically mediated, genetically manipulated and spontaneous models contribute valuable information regarding potential mechanisms involved in the initiation and perpetuation of chronic gut inflammation. One
Acknowledgments
We thank G. Kollias, S. Matsumoto, S.M. Cohn, M. McDuffie and K.F. Ley for their contributions to the development and characterization of TNF ΔARE and SAMP1/YitFc mice. The studies described in this article were supported by NIH grants DK42191, DK55812 and DK07769 to F.C.
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