Determinants of SR protein specificity

doi:10.1016/S0955-0674(99)80050-7

Current Opinion in Cell Biology

Volume 11, Issue 3, June 1999, Pages 358-362

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The SR (Ser-Arg) proteins are a family of nuclear factors that play multiple important roles in splicing of mRNA precursors in metazoan organisms, functioning in both constitutive and regulated splicing. Certain of these functions are redundant, such that any single SR proteins will suffice, but other functions are unique and are specific to a given family member. A number of studies during the past year have investigated the basis for SR protein specificity.

Abbreviations

dsx

doublesex

ESE

eonic splicing enhancer

PRE

purine-rich element

RBD

RNA-binding domain

RNP

ribonucleoprotein

SELEX

systematic evolution of ligands by exponential enrichment

SR protein

Ser-Arg protein

tet

tetracycline