Mechanisms of protein sorting and coat assembly: insights from the clathrin-coated vesicle pathway

https://doi.org/10.1016/S0955-0674(98)80065-3Get rights and content

Abstract

Clathrin-coated vesicles have provided the best example illustrating how both soluble and membrane proteins are selectively clustered into a transport intermediate for subsequent delivery to another intracellular compartment. Like cytosolic clathrin adaptors, the adaptor-like complex AP-3 binds to specific membranes and selects membrane proteins by interacting with their sorting signals.

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