Human fibulin-1D: Molecular cloning, expression and similarity with S1–5 protein, a new member of the fibulin gene family
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Fibulin-1 binds to fibroblast growth factor 8 with high affinity: Effects on embryo survival
2016, Journal of Biological ChemistryFibulin-1 purification from human plasma using affinity chromatography on Factor H-Sepharose
2016, Protein Expression and PurificationA novel intracellular fibulin-1D variant binds to the cytoplasmic domain of integrin beta 1 subunit
2015, Matrix BiologyCitation Excerpt :The 37 amino acid cytoplasmic domain peptide of integrin β1 was coupled to CNBR-activated sepharose beads (GE Biosciences, Pharmacia). Beads were incubated overnight at 4 °C with 5 μg of pFBLN1 or recombinant fibulin-1C (rFBLN1C), purified from conditioned media of transfected HT1080 cells [28], in TBS binding buffer containing 25 mM OG and 1 mM of CaCl2 and MgCl2. The supernatant (unbound fraction) was removed and beads were washed 4 times with binding buffer and 2 × non-reducing sample buffer was added.
Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel loci
2012, Biological PsychiatryCitation Excerpt :FBLN1 might also play a significant role in modulating the neurotrophic activities of amyloid precursor protein (35). Four splice variants, A–D, differing in the 3' end have been identified for FBLN1 (36). Although each variant encodes a different isoform, no functional distinctions have been identified among the four variants.
KSHV regulation of fibulin-2 in Kaposi's sarcoma: Implications for tumorigenesis
2011, American Journal of PathologyCitation Excerpt :Other fibulin isoforms (fibulin 1A, 1B) were not expressed at detectable levels in our transcription assay. This finding is consistent with results from other laboratories that report fibulin-1C and -1D are the predominantly expressed fibulin-1 spliced variants in various cell types and, further, that other fibulin-1 isoforms are not expressed or poorly expressed in these same cells.30 Different roles have been suggested for fibulin-1C and -1D based on their binding to the basement membrane protein nidogen.31