Original articleMalignant peripheral nerve sheath tumors in patients with and without neurofibromatosis
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Cited by (129)
Synchronous Development of Multicentric Malignant Peripheral Nerve Sheath Tumors: Institutional Review
2019, World NeurosurgeryCitation Excerpt :There have been only 2 cases of synchronous MPNST reported in the literature to date, and neither patient was reported as having NF-1.2,3 Multifocal presentation over time may be more common, with series ranging from 3.2%–45% of NF-1 patients with MPNST developing a second primary tumor over the long term.1,7 We did not identify any asynchronous, multifocal cases of MPNST in our cohort.
An intraosseous malignant peripheral nerve sheath tumor in the mandible of a patient with neurofibromatosis type 1
2018, Oral Science InternationalThe case of malignant peripheral nerve sheath tumor of the cheek
2016, Polish Annals of MedicineMalignant peripheral nerve sheath tumors of the head and neck: Demographics, clinicopathologic features, management, and treatment outcomes
2015, Oral OncologyCitation Excerpt :These tumors can arise either sporadically or in association with neurofibromatosis (NF). Neurofibromatosis type I (NF1), also known as von Recklinghausen’s disease, accounts for 40–50% of MPNST cases, with an average age of onset 10–15 years younger than in sporadic cases and a predilection for central anatomical locations [4–6]. While the development of MPNST in this population has been related to genetic insults involving p53 and p16, NF1 gene activity is believed to predispose patients to spontaneous development or transformation of Schwann cells from a preexisting benign neurofibroma [7–9].
The results of this study were presented at the Joint Meeting of the European Society of Surgical Oncology. British Association of Surgical Oncology, Chirurgische Arbeitsgemeinschaft Onkologie der Deutschen Gesellschaft für Chirurgie, Heidelberg, 8–11 June 1994.