Elsevier

Neuroscience Letters

Volume 273, Issue 2, 1 October 1999, Pages 140-141
Neuroscience Letters

Cathepsin D gene exon 2 polymorphism and sporadic Alzheimer's disease

https://doi.org/10.1016/S0304-3940(99)00635-7Get rights and content

Abstract

It has recently been reported that a genetic polymorphism in exon 2 of the cathepsin D gene conferred increased risk for development of Alzheimer's disease (AD). Because of the potential importance of this report we tested this association in a clinically well-defined group of AD patients and age and sex matched control subjects from the relatively genetically homogeneous Northern Ireland population. This study failed to confirm the reported association between the cathepsin D exon 2 polymorphism and AD. We conclude that if an association exists between this polymorphism and AD it is likely to be small.

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Acknowledgements

This work was funded by Ulster Garden Villages Limited and the DHSS NI.

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