Examination of the human prion protein-like gene Doppel for genetic susceptibility to sporadic and variant Creutzfeldt–Jakob disease
Section snippets
Acknowledgements
This work was funded by the Wellcome Trust and Medical Research Council. Dr T.H. Pringle is acknowledged for first reporting the bioinformatics of the Dpl gene and useful discussion. Ray Young assisted with figure design.
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2011, Progress in NeurobiologyExpression patterns of Doppel gene in golden hamster: Quantification using real-time RT-PCR
2008, Molecular and Cellular ProbesCitation Excerpt :Doppel (a prion-like protein, Dpl), encoded by Dpl gene, is located downstream of the prion protein (PrP) gene and Dpl shares significant biochemical and structural homology with the PrP [1]. Because PrPSc, the pathologic isoform of PrP, is considered the etiology of prion disease [2], some authors believe that the isolating of Dpl could help to further delineate the functionality of PrP and help identify the potential relevance of these two proteins in prion disease [3,4] However, in contrast to PrP, most researchers disagree with the idea that Dpl may be involved in the pathogenesis of prion disease [4–7]. Despite the controversial findings, there has been evidence demonstrating that Dpl was involved in tumor progression and diagnosis [8,9].
The prion protein family: Diversity, rivalry, and dysfunction
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