Beneficial effect of ursodeoxycholic acid on alterations induced by cholestasis of pregnancy in bile acid transport across the human placenta
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Cited by (99)
Cholesterol and early development
2022, Cholesterol: From Chemistry and Biophysics to the ClinicMitochondrial gene expression profiles are associated with intrahepatic cholestasis of pregnancy
2016, PlacentaCitation Excerpt :In this study we explored the association between ICP and changes in mitochondrial activity, as defined by the profiling of the expression of all 13 mitochondrial-encoded genes, mtDNA relative abundance and OS status. ICP has potentially severe short and long term effect on the progeny [2,3,5–7] and it is characterized by intracellular accumulation of bile acids in the placenta [3,7] affecting mitochondria [7,11,20–23]. We determined that the expression of 4 protein-coding mitochondrial-encoded genes, MT-ND4L, MT-ND4, MT-ND5 and MT-CYTB, is correlated to ICP.
Nuclear receptors, bile acids and cholesterol homeostasis series - Bile acids and pregnancy
2013, Molecular and Cellular EndocrinologyCitation Excerpt :These findings are consistent with reports of rodent models of cholestatic pregnancy in which there is a reversal in the transplacental gradient of bile acids towards the fetal circulation. This indicates impaired transport and detoxification of bile acids through the placental–maternal liver axis (Serrano et al., 1998). The principal bile acids that are raised in the fetal serum in ICP are conjugated CA and CDCA (Mazzella et al., 2001).
Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: Good, but can do better
2013, Clinics and Research in Hepatology and Gastroenterology