ArticlesAntibodies to glutamic acid decarboxylase as predictors of insulin-dependent diabetes mellitus before clinical onset of disease
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2021, Journal of the Formosan Medical AssociationPrevalence of double diabetes in youth onset diabetes patients from east Delhi and neighboring NCR region
2018, Diabetes and Metabolic Syndrome: Clinical Research and ReviewsCitation Excerpt :However Reinehr et al. who reported a higher prevalence of double diabetes (32%) have not mentioned the duration of diabetes in their study. It is unclear whether shorter duration of diabetes in these subjects resulted in a higher rate of antibody positivity [15,16], which might be an important factor underlying the difference in prevalence of double diabetes from our study. When the subjects in our study were analyzed considering the duration of diabetes we found highest antibody positive with shorter duration of diabetes mellitus.
Neurologic disorders associated with anti-glutamic acid decarboxylase antibodies: A comparison of anti-GAD antibody titers and time-dependent changes between neurologic disease and type I diabetes mellitus
2018, Journal of NeuroimmunologyCitation Excerpt :Pancreatic GAD is mainly GAD65, whereas the brain contains both isoforms. Anti-GAD antibodies have been detected in the early stage of type I diabetes mellitus (T1DM) in up to 80% of patients with the disease (Tuomilehto et al., 1994), as well as in the serum and cerebrospinal fluid (CSF) of patients with neurologic disease such as stiff person syndrome (SPS) (Solimena et al., 1988; Barker et al., 1998). Although anti-GAD antibody titers are usually low (< 100 IU/mL) in patients with T1DM, they are often high in those with SPS (Saiz et al., 2008).
Could ZnT8 antibodies replace ICA, GAD, IA2 and insulin antibodies in the diagnosis of type 1 diabetes?
2018, Current Research in Translational Medicine