Elsevier

The Lancet

Volume 329, Issue 8534, 21 March 1987, Pages 659-661
The Lancet

EVIDENCE THAT THE GENE FOR TUBEROUS SCLEROSIS IS ON CHROMOSOME 9

https://doi.org/10.1016/S0140-6736(87)90416-8Get rights and content

Abstract

Linkage analysis was undertaken in nineteen families with tuberous sclerosis by use of 26 polymorphic markers. All affected members fulfilled strict diagnostic criteria and unaffected members were rigorously investigated to confirm their status. Maximum lod scores were 1·20 for adenylate kinase 1 (AK1) at zero recombination and 3·85 for the ABO blood group at zero recombination (confidence limits 0-0·10). These findings support the assignment of the gene for tuberous sclerosis to the distal long arm of chromosome 9.

References (14)

  • Fa Flinter et al.

    Examining the parents of children with tuberous sclerosis

    Lancet

    (1986)
  • Jm Connor et al.

    Non-penetrance in tuberous sclerosis

    Lancet

    (1986)
  • A. Hunt et al.

    Tuberous sclerosis; a new estimate of prevalence within the Oxford region

    J Med Genet

    (1984)
  • MR. Gomez

    Tuberous sclerosis

    (1979)
  • Jc Alper et al.

    The incidence and significance of birthmarks in a cohort of 4641 newborns

    Pediatr Dermatol

    (1983)
  • Gm Farrow et al.

    Renal angiomyolipoma: A clinicopathologic study of 32 cases

    Cancer

    (1968)
There are more references available in the full text version of this article.

Cited by (0)

View full text