Original article
The renal lesion of the Laurence-Moon-Biedl syndrome*

https://doi.org/10.1016/S0022-3476(75)80580-4Get rights and content

In nine children with the Laurence-Moon-Biedl syndrome a high incidence of nephropathy was documented. Renal involvement was noted in seven patients before or simultaneously with the diagnosis of LMBS. Five have uremia and two have died. All patients had an abnormal urogram. The spectrum of renal lesions ranged from mesangial tissue proliferation to glomerular sclerosis, interstitial scarring, and medullary and cortical cyst formation. A relationship between the lesions seen in the LMBS and those of other hereditary retinal-renal conditions is suggested.

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*

Supported in part by M.R.C. term grant number MT-1579

Presented in part at the annual meeting of the Society for Pediatric Research, May, 1973, and at “Diagnostic Problems in Renal Biopsy” American Society of Nephrology, November 1973.

1

Dr. Hurley was the recipient of a fellowship from the Medical Research of Canada

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