Elsevier

The Journal of Pediatrics

Volume 65, Issue 3, September 1964, Pages 388-399
The Journal of Pediatrics

Heart disease in the Laurence-Moon-Biedl-Bardet syndrome: A review and a report of 3 brothers

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A summary of heart disease in the Laurence-Moon-Biedl-Bardet syndrome has not been published previously. Three male siblings, two of whom had congenital heart disease, are discussed. A review of the literature indicates that a variety of congenital cardiac malformations, occurring predominantly in males, may be found in this syndrome. Acquired heart disease, primarily hypertrophy of the left ventricle, is noted most frequently in association with renal disease and systemic hypertension. Necropsy reports suggest that the incidence of congenital and acquired heart disease is greater than one would surmise from the clinical reports of this entity.

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    Supported in part by Grant H-5407 (C3), National Heart Institute, and Grant 2A-5273, Developmental Physiology Training Program, from the National Institutes of Health; and also a grant from the Suncoast Heart Association of the Florida Heart Association.

    *

    Address, Department of Pediatrics, University of Florida College of Medicine, Gainesville, Fla.

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