Clinical-liver,pancreas, and biliary tractA novel MCP-1 gene polymorphism is associated with hepatic MCP-1 expression and severity of HCV-related liver disease☆
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Patients and controls
We studied retrospectively 206 patients (135 male, 71 female; mean age: 38.1 ± 13.0 years) with chronic hepatitis C (positive for HCV-RNA and anti-HCV) consecutively admitted to the hospital of the University of Regensburg. All patients were negative for hepatitis B surface antigen or antibodies to human immunodeficiency virus, and none of them had evidence of other types of liver disease. Risk factors for acquisition of hepatitis C infection were previous intravenous drug abuse in 28.2% of
Frequency of the −2518 MCP-1 polymorphism in patients with chronic HCV infection
The frequencies of the different MCP-1 genotypes A/A homozygotes, A/G heterozygotes, and G/G homozygotes are summarized in Table 1, revealing no significant differences between 206 patients with chronic hepatitis C infection and 139 healthy controls. Frequencies of individual genotypes were similar to those previously reported in other white control populations.15, 17, 19, 20
Because most previous in vitro and epidemiologic studies reported functional and disease-related differences mainly
Discussion
The results of this study demonstrate an association between different MCP-1 genotypes and hepatic fibrosis and inflammation in patients with chronic hepatitis C, confirming the initial hypothesis that host genetic factors may account for some of the variability in the rate of disease progression seen in these patients. This relationship between MCP-1 genotypes and hepatic fibrosis and inflammation is in accordance with the well-documented role of MCP-1 in the pathophysiology of chronic liver
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Supported by grants from the Deutsche Forschungsgemeinschaft (DFG; to A.B. and C.H.) and by the Else Kröner Fresenius-Stiftung (to C.H. and H.H.).