Clinical studyPrevalence of coronary heart disease associated with HFE mutations in adults attending a health appraisal center☆
Section snippets
Subjects and methods
The sample consisted of 30,916 white, non-Hispanic, adult patients aged 25 to 98 years who were attending the Health Appraisal Center at Kaiser Permanente, San Diego, California. All subjects gave informed consent to be screened for hemochromatosis by HFE genotyping. During any given 4-year period, approximately 81% of Kaiser enrollees attend the center; all patients attending were offered the opportunity to participate in the study. Those who consented represented 46% of all white,
Results
The sample consisted of 15,362 men (49.7%) and 15,554 women (Table 1). Mean transferrin saturation and ferritin levels varied by HFE genotype, with highest values occurring in C282Y homozygotes (C282Y/C282Y), followed by compound heterozygotes (C282Y/H63D), H63D homozygotes (H63D/H63D), C282Y heterozygotes (C282Y/wt), H63D heterozygotes (H63D/wt), and wild types (wt/wt) in both men and women (Table 1).
The overall prevalence of coronary heart disease was 12% (n = 1798) among men and 7% (n =
Discussion
In this large cross-sectional study of more than 30,000 white adults attending a health appraisal center, we found an increased odds of coronary heart disease among only one of 10 HFE genotype groups compared with sex-specific wild-type controls: male compound heterozygotes (C282Y/H63D) had a 1.6-fold increased odds of coronary heart disease after adjusting for age and other known cardiovascular risk factors. There were no significant associations among pooled carriers of the C282Y or the H63D
References (29)
Iron overload and atherosclerosis
Hepatology
(2000)- et al.
Iron status and risk of cardiovascular disease
Ann Epidemiol
(1997) - et al.
A prospective study of coronary heart disease and the hemochromatosis gene (HFE) C282Y mutationthe Atherosclerosis Risk in Communities (ARIC) study
Atherosclerosis
(2001) - et al.
Screening for hemochromatosisa cost-effectiveness study based on 12,258 patients
Gastroenterology
(1994) - et al.
Genotypic/phenotypic correlations in genetic hemochromatosisevolution of diagnostic criteria
Gastroenterology
(1998) - et al.
Analysis of the cost of population screening for haemochromatosis using biochemical and genetic markers
J Hepatol
(1997) - et al.
Lack of association between ferritin level and measures of LDL oxidationthe ARIC study. Atherosclerosis Risk in Communities
Atherosclerosis
(1998) - et al.
Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study
Am J Prev Med
(1998) - et al.
Iron, atherosclerosis, and ischemic heart disease
Arch Intern Med
(1999) - et al.
Iron and heart diseasethe epidemiologic data
Nutr Rev
(1996)
The effect of HFE genotypes in patients attending a health appraisal clinic
Ann Intern Med
Increased risk of acute myocardial infarction in carriers of the hemochromatosis gene Cys282Tyr mutationa prospective cohort study in men in eastern Finland
Circulation
Heterozygosity for a hereditary hemochromatosis gene is associated with cardiovascular death in women
Circulation
HFE gene mutations in coronary atherothrombotic disease
Braz J Med Biol Res
Cited by (0)
- ☆
Supported by grants DK53505-02 and RR00833 from the National Institutes of Health, Bethesda, Maryland, and supplemented with a grant from the Division of Nutrition and Physical Activity, Centers for Disease Control and Prevention, Atlanta, Georgia, and funds from the Stein Endowment Fund, San Diego, California.