CPx-type ATPases: a class of P-type ATPases that pump heavy metals

doi:10.1016/S0968-0004(96)20016-7

Trends in Biochemical Sciences

Volume 21, Issue 7, July 1996, Pages 237-241

https://doi.org/10.1016/S0968-0004(96)20016-7 Get rights and content

ATP-driven heavy metal pumps represent a newly defined class of proteins that translocate toxic and essential metals across biological membranes. These transporters form a separate evolutionary branch of the ion-transporting P-type ATPases. We propose to call these enzymes CPx-type ATPases, based on the common novel feature of a conserved intramembranous cysteine-proline-cysteine or cysteine-proline-histidine motif.

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¹: M. Solloz is at the Department of Clinical Pharmacology, University of Berne, Murtenstrasse 35, 3010 Berne, Switzerland.

²: C. Vulpe is at the Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143-0748, USA.

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Trends in Biochemical Sciences

CPx-type ATPases: a class of P-type ATPases that pump heavy metals

Trends Biochem. Sci.

Trends Biochem. Sci.

Trends Biochem. Sci.

J. Biol. Chem.

Biochem. Biophys. Res. Commun.

J. Biol. Chem.

J. Biol. Chem.

Biochem. Biophys. Res. Commun.

FEMS Microbiol. Rev.

Cell

J. Mol. Biol.

J. Bacteriol.

Ann. New York Acad. Sci.

Nat. Genet.

Nat. Genet.